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首页> 外文期刊>Journal of Chemical Engineering of Japan >Crystal Quality Control by Using the Millimeter-Size Tube Type Taylor Vortex Continuous Crystallizer
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Crystal Quality Control by Using the Millimeter-Size Tube Type Taylor Vortex Continuous Crystallizer

机译：使用毫米管型泰勒涡旋连续结晶器进行晶体质量控制

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摘要

Introduction of a continuous production system to the pharmaceutical field has become realistic. In this field, many kinds of organic crystals with high anisotropic aspect are produced. Hence, crystal morphology affects the pharmaceutical productivity. Therefore, a high production method with crystal morphology improvement currently attracts attention by using a continuous crystallizer. In order to improve the production rate, it is necessary to enhance the crystal growth rate by increasing the mass transfer. The stirring method using Taylor Vortex has been developed in the crystallization research field. The objectives of this study are to design a double-cylinder shaped milli-size crystallizer in order to realize Taylor Vortex, and to evaluate the productivity and crystal morphology. As a result, it was clear that the proposed crystallizer had a productivity about 40 times greater than a conventional batch crystallizer and had a performance which improved the aspect ratio by 59%.
机译：将连续生产系统引入制药领域已成为现实。在该领域中，生产了具有高各向异性的多种有机晶体。因此，晶体形态影响药物生产率。因此，目前，通过使用连续结晶器，具有改善晶体形态的高产量方法引起了人们的注意。为了提高生产率，必须通过增加传质来提高晶体生长速度。在结晶研究领域中已经开发出使用泰勒涡旋的搅拌方法。这项研究的目的是设计一个双圆筒形的毫米结晶器，以实现泰勒涡旋，并评估生产率和晶体形态。结果，很明显，所提出的结晶器的生产率是常规间歇结晶器的约40倍，并且具有将长径比提高59％的性能。

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