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首页> 外文期刊>Journal of Clinical Medicine >Serum Vitamin E Levels of Adults with Nonalcoholic Fatty Liver Disease: An Inverse Relationship with All-Cause Mortality in Non-Diabetic but Not in Pre-Diabetic or Diabetic Subjects
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Serum Vitamin E Levels of Adults with Nonalcoholic Fatty Liver Disease: An Inverse Relationship with All-Cause Mortality in Non-Diabetic but Not in Pre-Diabetic or Diabetic Subjects

机译：成人非酒精性脂肪肝疾病的血清维生素E水平：与非糖尿病而非糖尿病前期或糖尿病患者的全因死亡率成反比关系

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Nonalcoholic fatty liver disease (NAFLD) is a growing health threat worldwide. Vitamin E supplementation is recommended for nonalcoholic steatohepatitis (NASH) patients, but only for non-diabetic subjects. We aimed to investigate whether serum vitamin E levels differently impact long-term prognosis in diabetic versus non-diabetic NAFLD individuals. A total of 2404 ultrasonographically defined NAFLD individuals from National Health and Nutrition Examination Survey (NHANES) III were stratified by their glycemic statuses into diabetic ( N = 662), pre-diabetic ( N = 836) and non-diabetic ( N = 906), and the relationship between serum vitamin E levels and all-cause mortality was analyzed. The serum vitamin E concentrations were 31.1 ± 14.1, 26.7 ± 9.6, and 24.7 ± 9.8 μmol/L and vitamin E: total cholesterol ratios were 5.16 ± 1.70, 4.81 ± 1.46, and 4.80 ± 1.34 μmol/mmol in in diabetic, pre-diabetic, and non-diabetic groups, respectively. Of 2404 NAFLD subjects, 2403 have mortality information and 152 non-diabetic, 244 pre-diabetic, and 342 diabetic participants died over a median follow-up period of 18.8 years. Both serum vitamin E levels and vitamin E: total cholesterol ratios were negatively associated with all-cause mortality after adjusting for possible confounders in non-diabetic subjects (HR = 0.483, and 0.451, respectively, p 0.005), but not in either diabetic or pre-diabetic subjects. In NAFLD individuals, both serum vitamin E and lipid-corrected vitamin E were (1) higher in the diabetic group; and (2) negatively associated with all-cause mortality only in the non-diabetic group. Further investigations are warranted to elucidate the underlying mechanism of this inverse association of serum vitamin E concentration with all-cause mortality in non-diabetic but not pre-diabetic or diabetic subjects.
机译：非酒精性脂肪肝疾病（NAFLD）在世界范围内对健康的威胁日益增加。对于非酒精性脂肪性肝炎（NASH）患者，建议补充维生素E，但仅限非糖尿病患者。我们旨在研究在糖尿病和非糖尿病NAFLD患者中，血清维生素E水平是否会影响长期预后。根据美国国家卫生和营养检查调查（NHANES）III的2404例超声检查NAFLD患者，其血糖状态分为糖尿病（N = 662），糖尿病前（N = 836）和非糖尿病（N = 906）。 ，并分析了血清维生素E水平与全因死亡率之间的关系。糖尿病前期糖尿病患者的血清维生素E浓度为31.1±14.1、26.7±9.6和24.7±9.8μmol/ L，维生素E：总胆固醇比为5.16±1.70、4.81±1.46和4.80±1.34μmol/ mmol。糖尿病和非糖尿病人群。在2404名NAFLD受试者中，有2403名具有死亡率信息，152名非糖尿病患者，244名糖尿病前患者和342名糖尿病患者在中位随访期18.8年内死亡。在调整了非糖尿病患者的可能混杂因素后，血清维生素E水平和维生素E：总胆固醇比率与全因死亡率均呈负相关（HR分别为0.483和0.451，p <0.005），但在任一糖尿病患者中均没有或糖尿病前期的受试者。在NAFLD个体中，糖尿病组的血清维生素E和经脂质校正的维生素E均较高（1）; （2）仅在非糖尿病组中与全因死亡率负相关。有必要进行进一步的研究来阐明血清维生素E浓度与非糖尿病患者（而非糖尿病前或糖尿病患者）全因死亡率之间这种负相关的潜在机制。

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