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首页> 外文期刊>Journal of Clinical Medicine and Research >Pulmonary and extra pulmonary manifestations of Aspergillosis in clinical practice and potential challenges in management: An analysis of literature review
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Pulmonary and extra pulmonary manifestations of Aspergillosis in clinical practice and potential challenges in management: An analysis of literature review

机译：曲霉病的肺部和肺外表现在临床实践中和管理中的潜在挑战：文献综述分析

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With various factors causing immunosuppression among humans and tendency towards opportunistic fungal infections such as aspergillosis, this study was therefore set up to assess the associated changing clinical presentations of the disease from the developing world. The study was based on literature search from available reports on clinical presentations of aspergillosis from literature searches for a period of 20 years (1990 - 2010). The most common forms of presentations of aspergillosis documented from the 9,743 patients in 1,222 literature reviews were invasive?Pulmonary aspergillosis34.53% (3,365), allergic bronchopulmonary aspergillosis 18.13% (1,767),?Pulmonary aspergillomas?15.41% (1,501) and aspergillosis of maxillary sinuses 8.05% (784). Some of the rarest presentations were aspergillus aortic embolism with stroke 0.04%, tension pneumothorax 0.07%, mycotic aneurism of descending thoracic aorta 0.06%, skull base erosion by sphenoid fungal balls 0.02%, small bowel obstruction 0.16%, perforation of large intestine 0.04%, small bowel infarction 0.03%, hypertrophic cranial pachmeningitis 0.34% and invasive generalised multi-organ aspergillosis 0.44%. Aspergillosis was found to present with various unusual surgical or medical emergencies with overall infection rates significantly higher in immunocompromised (P < 0.0001). In patients presenting with quite familiar clinical pictures in the developing world but proving difficult for treatment especially in the immunosuppressed but not exclusive and where facilities for diagnosis may be lacking, aspergillosis should not be completely ruled out.
机译：由于各种因素导致人类之间的免疫抑制以及趋向于机会性真菌感染，例如曲霉菌病，因此，本研究旨在评估来自发展中国家的疾病的相关临床表现。这项研究基于20年来（1990年至2010年）通过文献检索获得的有关曲霉病临床表现的文献检索。在1,222篇文献中，从9,743例患者中记录的最常见形式的曲霉病表现为浸润性？肺曲霉病34.53％（3,365），变应性支气管肺曲霉病18.13％（1,767）、?肺曲霉菌病15.41％（1,501）和曲霉病。上颌窦8.05％（784）。最罕见的表现为曲霉性主动脉栓塞伴卒中0.04％，张力性气胸0.07％，胸主动脉降支霉菌性动脉瘤0.06％，蝶骨真菌球侵蚀颅底0.02％，小肠梗阻0.16％，大肠穿孔0.04％ ，小肠梗塞为0.03％，肥厚性颅脑膜炎为0.34％，浸润性多器官曲霉病为0.44％。发现曲霉病表现为各种异常的外科或医学紧急情况，其免疫功能低下的总体感染率明显更高（P <0.0001）。对于在发展中国家表现出相当熟悉的临床表现但被证明难以治疗的患者，尤其是在免疫抑制但非排他性疾病且可能缺乏诊断设施的患者中，不应完全排除曲霉病。

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