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首页> 外文期刊>Journal of Clinical Medicine and Research >Haematological profile of sickle cell anaemia in children with human parvovirus B19 infection in Jos, North Central Nigeria
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Haematological profile of sickle cell anaemia in children with human parvovirus B19 infection in Jos, North Central Nigeria

机译：尼日利亚中北部乔斯人细小病毒B19感染儿童镰状细胞贫血的血液学特征

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The recognition and characterization of haematological alterations accompanying viral infections could serve as tools for diagnosis, assist in disease prognosis and improve patient management. This paper aims to evaluate the haematological profile of parvovirus B19 antibody positive sickle cell patients, who are inherently prone to morbidity and mortality from parvovirus infection. A total of 200 sickle cell patients aged 1 to 18 years were recruited into the study. Screening for IgG and IgM parvovirus B19 antibodies were done using Elisa Kit (Institut Viron/serion GMbH Wurzbury, Germany). Complete blood count (PCV: Packed cell volume, WBC: White cell count, Platelet count) and reticulocyte count were carried out on all subjects using automated coulter machine. The mean Platelet count was significantly lower among IgM antibody seropositive children compared to those who are seronegative (p < 0.05). Children who were IgM antibody seropositive had a significantly higher mean reticulocyte count and index (P < 0.05). IgG seropositivity was not associated with any significant alteration in these haematological parameters. Haematological alterations could occur in sickle cell anaemia children during acute infection with the human parvovirus B19. It is recommended that clinicians caring for these patients be made more aware of the existence of this virus as well as the possible haematological alterations that could accompany it in our environment. Hospital laboratories should be encouraged to introduce diagnostic tests for parvovirus B19 infection.
机译：识别和表征伴随病毒感染的血液学改变可作为诊断工具，帮助疾病预后和改善患者管理。本文旨在评估细小病毒B19抗体阳性的镰状细胞患者的血液学特征，这些患者天生易因细小病毒感染而发病和死亡。该研究共招募了200名1至18岁的镰状细胞患者。使用Elisa Kit（Institut Viron / serion GMbH Wurzbury，德国）筛选IgG和IgM细小病毒B19抗体。使用自动库尔特机对所有受试者进行全血细胞计数（PCV：包装细胞体积，WBC：白细胞计数，血小板计数）和网织红细胞计数。与血清反应阴性的儿童相比，IgM抗体血清反应阳性的儿童的平均血小板计数显着降低（p <0.05）。 IgM抗体血清阳性的儿童的平均网织红细胞计数和指数更高（P <0.05）。 IgG血清阳性与这些血液学参数的任何重大改变均无关。在人类细小病毒B19急性感染期间，镰状细胞性贫血儿童可能会发生血液学改变。建议让照顾这些患者的临床医生更多地了解这种病毒的存在以及在我们的环境中可能伴随该病毒的血液学改变。应鼓励医院实验室引入细小病毒B19感染的诊断测试。

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