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首页> 外文期刊>Journal of Clinical Medicine and Research >Acute effect of diazinon on blood plasma biochemistry in the African catfish (Clarias gariepinus)
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Acute effect of diazinon on blood plasma biochemistry in the African catfish (Clarias gariepinus)

机译：二嗪农对非洲cat鱼（Clarias gariepinus）血浆生化的急性影响

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The acute effect of diazinon on the African catfish (Clarias gariepinus)?was assessed by comparing the biochemical blood plasma profiles of a control group and a group exposed to the effect of the pesticide DiazintolR?(162 mg/ml of diazinon as the active substance). The activities of selected enzymes, metabolite and electrolytes concentrations were measured on 16 specimens of controls, and in 20 specimens, of (C. gariepinus?of mean weight 350 ± 15 g, and mean total length 35 ± 2.0 cm) exposed for 96 h to the effects of DiazintolR?at a concentration of 6.6 ppm. The results showed a significant decrease of cholinesterase (p < 0.05) lactate dehydrogenase (p?< 0.05) alkaline phosphatase and acid phosphatase in the experimental group. The values of alanine and aspartate, aminotransferases, creatine kinase, were comparable in the experimental and control groups. A significant decrease (p?< 0.05) was observed in the total protein, albumin globulin and lactate concentration in the experimental group compared with the control group. Glucose concentration in the plasma of the experimental group was significantly higher (p?< 0.05) than that of the control group. A significantly higher (p < 0.05) concentration of plasma sodium and potassium was observed in the experimental group and a significantly lower (p?< 0.05) concentration of plasma calcium and phosphorus, compared with those in the control group. The results of the biochemical blood plasma profile indicate a marked neurotoxic effect of diazinon and shows that this changes could be used as biomarkers for aquatic pollution.
机译：通过比较对照组和暴露于杀虫剂DiazintolRα（162 mg / ml的地嗪农活性物质）的对照组的生化血浆分布，评估了地嗪农对非洲cat鱼（Clarias gariepinus）的急性作用。 ）。在对照组的16个标本和20个标本中暴露了96小时的（C. gariepinus？平均体重350±15 g，平均总长度35±2.0 cm）的样本中测量了所选酶，代谢产物和电解质的活性。浓度为6.6 ppm时对DiazintolR？的影响。结果表明，实验组胆碱酯酶（p <0.05）乳酸脱氢酶（p <0.05）显着降低。实验组和对照组的丙氨酸和天冬氨酸，氨基转移酶，肌酸激酶的值相当。与对照组相比，实验组的总蛋白，白蛋白球蛋白和乳酸浓度明显降低（p <0.05）。实验组血浆中的葡萄糖浓度明显高于对照组（p <0.05）。与对照组相比，实验组中血浆钠和钾的浓度显着较高（p <0.05），血浆钙和磷的浓度显着较低（p <0.05）。血浆生化曲线的结果表明二嗪农具有明显的神经毒性作用，并表明该变化可用作水生生物污染的生物标志物。

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