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首页> 外文期刊>Journal of Clinical Medicine and Research >Prospective study of ingestional hair dye poisoning in Northern India (Prohina)
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Prospective study of ingestional hair dye poisoning in Northern India (Prohina)

机译：印度北部（Prohina）的染发性染毒中毒的前瞻性研究

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Hair dye (paraphenylene di-amine, PPD) poisoning has high morbidity and mortality and its incidence has increased dramatically in the past 4 years. A prospective study was planned to assess the clinical profile and outcome with different treatment approaches and mortality rate in patients with hair dye ingestion. The material comprised 1020 cases admitted in Medicine Department of MLB Medical College, Jhansi, U. P. from July 2004 to March 2009. Out of 1020 cases, 697 cases were of stone hair dye poisoning and 323 cases were of other branded hair dyes (powdered form containing less amount of paraphenylene diamine). Diagnosis was made solely on the basis of the history given by cases/attendant and symptoms of neck swelling, black colored urine and muscular pain. The cases were thoroughly studied for different complications (renal, hepatic and cardiac etc) and were treated accordingly. Out of 1020 cases studied, majority were females in the age group of 15 to 45 years (n=734) while the rest were males. A total of 161 (15.78%) cases expired during treatment. Neck swelling, respiratory distress and whole body muscular pain were most common symptoms at presentation, oliguria, chest pain, palpitation, presyncope/syncope, pain in abdomen, nausea with vomiting and dysphagia were other common symptoms. Paraphenylene diamine is highly toxic. Cases who consumed up to 10 gm of PPD usually survived if they are presented to hospital within 4 h of dye ingestion in whom proper management can be delivered in the form of i/v methyl prednisolone and other supportive care. Severe edema of face, neck and floor of mouth, renal failure and myocarditis were poor prognostic factors.
机译：染发剂（对苯二胺，PPD）中毒的发生率和死亡率很高，并且在过去4年中其发病率急剧上升。计划进行一项前瞻性研究，以评估摄入染发剂的患者使用不同治疗方法和死亡率的临床概况和结果。该材料包括2004年7月至2009年3月在美国约翰内斯堡市MLB医学院医学系收治的1020例病例。在1020例病例中，有697例石染染毒，323例其他品牌染发剂（粉状含较少量的对苯二胺）。仅根据病例/护理人员的病史以及颈部肿胀，黑色尿液和肌肉疼痛的症状进行诊断。对这些病例进行了彻底的研究以了解其不同的并发症（肾脏，肝脏和心脏等），并进行了相应的治疗。在研究的1020例病例中，年龄在15至45岁（n = 734）的年龄组中，多数为女性，其余为男性。治疗期间共有161例（15.78％）病例死亡。颈部肿胀，呼吸窘迫和全身肌肉疼痛是最常见的症状，少尿，胸痛，心慌，晕厥/晕厥，腹部疼痛，恶心，呕吐和吞咽困难是其他常见症状。对苯二胺是剧毒的。如果PPD摄入量达到10 gm，则通常在他们摄入染料后4小时内就诊，这些患者可以通过i / v甲基泼尼松龙和其他支持治疗的形式进行适当管理。严重的面部，颈部和口底水肿，肾衰竭和心肌炎是不良的预后因素。

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