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首页> 外文期刊>Journal of Clinical Medicine and Research >The serum levels of P-cresol and Indoxyl sulfate in different hemodialysis vintage
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The serum levels of P-cresol and Indoxyl sulfate in different hemodialysis vintage

机译：不同血液透析年份血清对甲酚和硫酸吲哚酚的水平

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Indoxyl sulfate (IS) and para-cresol (p-cresol) belong to the group of protein-bound uremic toxins that are poorly cleared by dialysis and are associated with poor clinical outcomes. The goal of our study was to evaluate the relationship between dialysis time and serum levels of IS and?p-cresol in hemodialysis (HD) patients. Our study enrolled 96 stable HD patients who were categorized into 8 subgroups on the basis of the duration for which they received dialysis within a period of 1 year. Patients with acute infection, malignancy or those who were younger than 18 years of age were excluded. Serum levels of total and free p-cresol and indoxyl sulfate were measured using ultra performance liquid chromatography (UPLC). Biochemical data was also collected concurrently. In our study, we found that only unbound IS and total IS were significantly and positively correlated with the dialysis time in HD patients by trend analysis (p= 0.020 and p=0.007, respectively). Other independent variables, including the levels of unbound p-cresol, total p-cresol, hemoglobin, highly sensitive?C-reactive protein?(CRP), Kt/V and albumin, did not show significant correlation with the length of HD treatment. Our results inferred that patients undergoing longer hemodialsysis may lead to higher serum levels of IS.
机译：硫酸吲哚酚（IS）和对甲酚（p-甲酚）属于蛋白结合型尿毒症毒素，透析后清除效果较差，并且与临床效果不佳相关。我们研究的目的是评估血液透析（HD）患者的透析时间与IS和β-甲酚血清水平之间的关系。我们的研究招募了96名稳定的HD患者，根据他们在1年内接受透析的时间长短，将其分为8个亚组。排除了急性感染，恶性肿瘤或18岁以下的患者。使用超高效液相色谱（UPLC）测量血清中总和游离对甲酚和硫酸吲哚酚的水平。同时还收集了生化数据。在我们的研究中，我们发现通过趋势分析，只有未结合的IS和总IS与HD患者的透析时间显着正相关（分别为p = 0.020和p = 0.007）。其他独立变量，包括未结合的对甲酚含量，总对甲酚含量，血红蛋白，高度敏感的？C反应蛋白？（CRP），Kt / V和白蛋白，与HD治疗时间没有显着相关性。我们的研究结果表明，接受更长的血液透析治疗的患者可能会导致更高的IS血清水平。

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