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首页> 外文期刊>Journal of Clinical Medicine Research >C-Reactive Protein and Frailty in the Elderly: A Literature Review
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C-Reactive Protein and Frailty in the Elderly: A Literature Review

机译：C反应蛋白和老年人体弱：文献综述。

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Chronic inflammation is a well-established background process in many age-related diseases. Many recent studies investigate the use of various inflammatory biomarkers such as C-reactive protein (CRP), interleukin-6, and interleukin-1 as predictors of physical and cognitive performance among elders. The phenotype of frailty has also been associated with underlying inflammatory mechanisms. The aim of this article was to review the literature referring to the correlation of CRP serum levels and frailty in older individuals. We tried to identify all relevant publications regarding the relation of CRP as an index of frailty in the elderly and its potential use. Although many studies in the recent medical literature positively associate serum CRP levels and frailty in older individuals, some do not, and some raise some interesting questions and set the basis for future studies. The association of CRP and frailty in elder patients should be considered when clinicians interpret inflammatory biomarkers in various clinical settings in such patients. Well-designed, prospective clinical trials are warranted to better assess the role and pathophysiology of frailty in the elderly and its mechanisms as also the exact role of CRP as an inflammatory marker and as a prognostic index in this syndrome.J Clin Med Res. 2017;9(6):461-465doi: https://doi.org/10.14740/jocmr2959w
机译：在许多与年龄有关的疾病中，慢性炎症是公认的背景过程。最近的许多研究调查了各种炎症生物标记物（例如C反应蛋白（CRP），白细胞介素6和白细胞介素1）在老年人身体和认知表现中的预测作用。脆弱的表型也与潜在的炎症机制有关。本文的目的是回顾有关老年人CRP血清水平与体弱相关的文献。我们试图找出所有有关CRP作为老年人体弱指数的指标及其潜在用途的相关出版物。尽管最近医学文献中的许多研究都将老年患者的血清CRP水平和体弱相关联，但有些却没有，有些提出了一些有趣的问题，并为以后的研究奠定了基础。当临床医生在此类患者的各种临床环境中解释炎症生物标志物时，应考虑CRP与年老体弱的关系。经过精心设计的前瞻性临床试验可更好地评估老年人体弱的作用和病理生理及其机制，以及CRP作为该综合征的炎症标志物和预后指标的确切作用.J Clin Med Res。 2017; 9（6）：461-465doi：https://doi.org/10.14740/jocmr2959w

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