...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Medicine Research >Prospective Identification of Oligoclonal/Abnormal Band of the Same Immunoglobulin Type as the Malignant Clone by Differential Location of M-Spike and Oligoclonal Band
【24h】

Prospective Identification of Oligoclonal/Abnormal Band of the Same Immunoglobulin Type as the Malignant Clone by Differential Location of M-Spike and Oligoclonal Band

机译：通过M-Spike和寡克隆带的不同位置来前瞻性鉴定与恶性克隆相同的免疫球蛋白类型的寡克隆/异常带

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Serum and urine protein electrophoreses and immunofixation electrophoreses are the gold standards in diagnosing monoclonal gammopathy. Identification of oligoclonal bands in post-treatment patients has emerged as an important issue and recording the location of the malignant monoclonal peak may facilitate prospective identification of a new “monoclonal” spike as being distinct from the malignant peak.Methods: We recorded the locations of monoclonal spikes in descriptive terms, such as being in the cathodal region, mid-gamma region, anodal region, and beta region. The location of monoclonal or restricted heterogeneity bands in subsequent protein electrophoreses was compared to the location of the original malignant spike.Results: In a patient with plasma cell myeloma, the original monoclonal IgG kappa band was located at the anodal end of gamma region. Post-treatment, an IgG kappa band was noted in mid-gamma region and the primary malignant clone was not detectable by serum protein immunofixation electrophoresis (SIFE) in post-treatment sample. Even though the κ/λ ratio remained abnormal, we were able to recognize stringent complete response by noting the different location of the new IgG kappa band as a benign regenerative process.Conclusions: Recording the location of the malignant monoclonal spike facilitates the identification of post-treatment oligoclonal bands, prospectively. Recognizing the regenerative, benign, bands in post-transplant patients facilitates the determination of stringent complete response despite an abnormal κ/λ ratio.J Clin Med Res. 2017;9(10):826-830doi: https://doi.org/10.14740/jocmr3109w
机译：背景：血清和尿蛋白电泳和免疫固定电泳是诊断单克隆性丙种球蛋白病的金标准。在治疗后患者中鉴定寡克隆带已成为一个重要问题，并且记录恶性单克隆峰的位置可能有助于前瞻性鉴定与恶性峰不同的新“单克隆”峰。方法：我们记录了用描述性术语表示的单克隆尖峰，例如在阴极区，中伽玛区，阳极区和β区。将随后的蛋白质电泳中的单克隆或受限异质性条带的位置与原始恶性刺突的位置进行了比较。结果：在浆细胞性骨髓瘤患者中，原始单克隆IgG kappa条带位于伽玛区域的阳极末端。治疗后，在中γ区域发现了一个IgGκ带，并且通过治疗后样品中的血清蛋白免疫固定电泳（SIFE）无法检测到原发性恶性克隆。即使κ/λ比值仍保持异常，我们仍可以通过注意到新的IgGκ带的不同位置来识别良性再生过程，从而识别出严格的完全反应。前瞻性地处理寡克隆带。认识到移植后患者中的再生性良性条带有助于确定严格的完全反应，尽管κ/λ比值异常。 2017; 9（10）：826-830doi：https://doi.org/10.14740/jocmr3109w

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号