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首页> 外文期刊>Journal of Clinical Medicine Research >External Validation of the LabBM Score in Patients With Brain Metastases
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External Validation of the LabBM Score in Patients With Brain Metastases

机译：脑转移患者的LabBM评分的外部验证

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Background: The aim of this study was to validate the prognostic impact of the recently introduced three-tiered LabBM score in patients with brain metastases. In contrast to the previous development and validation cohorts, the present cohort did not include patients treated with primary surgery and/or radiosurgery. The score is based on hemoglobin, platelet counts, albumin, C-reactive protein and lactate dehydrogenase. Methods: This was a retrospective single institution analysis. Overall, 167 patients managed with first-line whole-brain radiotherapy (WBRT) were identified from a prospectively maintained database. Results: The LabBM score significantly predicted overall survival (median 4.0, 2.9 and 1.5 months, respectively). Conclusions: The LabBM score is also valid in a patient population that differs from the previously studied cohorts, that is patients who were judged to be better candidates for WBRT than surgery or radiosurgery. As these patients in general represent a less favorable subset, their median survival was shorter than reported in the development cohort (11, 7 and 3 months, respectively). Future studies should examine whether or not combinations of the LabBM and other scores, for example, lung-molGPA and melanoma-molGPA, improve the clinical value of single scores.
机译：背景：本研究的目的是验证最近引入的三层LabBM评分对脑转移患者的预后影响。与先前的开发和验证队列相反，本队列不包括接受初次手术和/或放射外科手术治疗的患者。得分基于血红蛋白，血小板计数，白蛋白，C反应蛋白和乳酸脱氢酶。方法：这是一项回顾性单一机构分析。总体上，从前瞻性维护的数据库中识别出167例接受一线全脑放射治疗（WBRT）治疗的患者。结果：LabBM评分显着预测了总生存期（分别为中位数4.0、2.9和1.5个月）。结论：LabBM评分在不同于先前研究队列的患者人群中也有效，即被认为比手术或放射外科手术更适合WBRT的患者。由于这些患者通常代表较差的亚组，因此其中位生存期短于发育队列中报道的时间（分别为11、7和3个月）。未来的研究应检查LabBM和其他分数（例如肺-molGPA和黑素瘤-molGPA）的组合是否提高单项得分的临床价值。

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