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首页> 外文期刊>Journal of Clinical Medicine Research >Humoral and Cellular Patterns of Early Endothelial Progenitor Cells in Relation to the Cardiovascular Risk in Axial Spondylarthritis
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Humoral and Cellular Patterns of Early Endothelial Progenitor Cells in Relation to the Cardiovascular Risk in Axial Spondylarthritis

机译：早期内皮祖细胞的体液和细胞模式与轴突性脊柱炎的心血管风险相关

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Background: Spondylarthritis (SpA) significantly affects sacroiliac, intervertebral and peripheral joints. Patients with SpA suffer from increased cardiovascular risk (CVR). The endothelial progenitor cell (EPC) system critically perpetuates vascular repair. The aim of the study was to evaluate circulating EPCs in axial (ax)SpA with special attention on parameters of disease activity and CVR. Methods: Disease activity and functional impairment were quantified in 50 axSpA patients by using standardized parameters (Bath ankylosing spondylitis disease activity index (BASDAI), C-reactive protein (CRP), finger-floor distance (FFD) and Ott’ sign). Circulating EPCs and EPC regeneration were analyzed (fluorescence-activated cell sorting (FACS) and colony-forming unit (CFU) assay). Serum vasomodulatory mediators were quantified by enzyme-linked immunosorbent assay (ELISA). Results: EPC colony numbers were lower in axSpA as compared to controls. Females displayed more colonies than males. In addition, fewer colonies were observed in smokers, in patients with a BASDAI of below 4 and in hypertension. Circulating CD133sup+/sup/KDRsup+/sup cells did not differ between the groups. Follow-up analysis (33 months later) did not show any differences in gender, colony formation, CD133sup+/sup/KDRsup+/sup cells or serum levels of vasomodulatory mediators if related to the categories of BASDAI, Ott’ sign or FFD. Conclusions: EPC colony formation is significantly affected in axSpA with particularly low levels in males. EPC-related parameters do not allow predicting disease activity-related or functional parameters nor are they useful for CVR assessment in SpA.
机译：背景：腰椎炎（SpA）会严重影响sa，椎间和外周关节。 SpA患者患有心血管风险（CVR）增加。内皮祖细胞（EPC）系统可永久维持血管修复。这项研究的目的是评估轴向（ax）SpA中的循环EPC，并特别注意疾病活动性和CVR的参数。方法：采用标准化参数（巴氏强直性脊柱炎疾病活动指数（BASDAI），C反应蛋白（CRP），手指距离（FFD）和Ott'征）对50例axSpA患者的疾病活动和功能障碍进行定量。分析循环EPC和EPC再生（荧光激活细胞分选（FACS）和集落形成单位（CFU）分析）。血清血管调节介质通过酶联免疫吸附测定（ELISA）进行定量。结果：与对照组相比，axSpA中的EPC菌落数更低。女性显示出比男性更多的菌落。此外，在吸烟者，BASDAI低于4的患者和高血压患者中观察到的菌落较少。各组之间的循环CD133 + / KDR + 细胞没有差异。随访分析（33个月后）未发现与性别，集落形成，CD133 + / KDR + 细胞或血清中血管调节因子水平有关的任何差异。 BASDAI，Ott'符号或FFD的类别。结论：axSpA中EPC菌落的形成受到显着影响，而男性中的水平特别低。 EPC相关参数不允许预测疾病活动相关参数或功能参数，也不适用于SpA中的CVR评估。

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