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首页> 外文期刊>Journal of Clinical Medicine >Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development
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Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development

机译：神经C和体节发育过程中的上皮-间质转变

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Epithelial-to-mesenchymal transition (EMT) is a central process during embryonic development that affects selected progenitor cells of all three germ layers. In addition to driving the onset of cellular migrations and subsequent tissue morphogenesis, the dynamic conversions of epithelium into mesenchyme and vice-versa are intimately associated with the segregation of homogeneous precursors into distinct fates. The neural crest and somites, progenitors of the peripheral nervous system and of skeletal tissues, respectively, beautifully illustrate the significance of EMT to the above processes. Ongoing studies progressively elucidate the gene networks underlying EMT in each system, highlighting the similarities and differences between them. Knowledge of the mechanistic logic of this normal ontogenetic process should provide important insights to the understanding of pathological conditions such as cancer metastasis, which shares some common molecular themes.
机译：上皮到间质转化（EMT）是胚胎发育过程中的一个核心过程，它影响所有三个胚层的选定祖细胞。除了驱动细胞迁移和随后的组织形态发生的开始，上皮向间充质的动态转化以及反之亦然，与均质前体向不同命运的分离密切相关。分别是周围神经系统和骨骼组织的祖先，神经c和体节，很好地说明了EMT对上述过程的重要性。正在进行的研究逐步阐明了每个系统中EMT的基因网络，强调了它们之间的异同。对这种正常个体发生过程的机制逻辑的了解应该为理解病理状况（例如癌转移）提供重要的见识，而癌转移具有一些共同的分子主题。

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