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首页> 外文期刊>Journal of Clinical Medicine Research >Antioxidant Vitamins and Lipoperoxidation in Non-pregnant, Pregnant, and Gestational Diabetic Women: Erythrocytes Osmotic Fragility Profiles
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Antioxidant Vitamins and Lipoperoxidation in Non-pregnant, Pregnant, and Gestational Diabetic Women: Erythrocytes Osmotic Fragility Profiles

机译：非孕妇，孕妇和妊娠糖尿病妇女的抗氧化剂维生素和脂过氧化：红细胞渗透性脆弱性

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Background:?Inconsistent reports are available in the literature regarding the oxidative status and antioxidant capacity during the pathogenesis of gestational diabetes. Present study was aimed to evaluate oxidative stress during the development of gestational diabetes and to evaluate antioxidant capability in non-pregnant (control), pregnant and gestational diabetics.Methods: The study consisted of non-pregnant, healthy pregnant and patients suffering from gestational diabetes mellitus (GDM). Each group consisted of 23 women. We compared their oxidative and anti-oxidative system in blood. Their blood malondialdehyde (MDA) and antioxidant vitamins (C, E, A) were determined and compared to evaluate the oxidative status and anti-oxidative capacity of these groups. We have also compared the osmotic fragility profiles of the erythrocytes of these groups. Results: Plasma MDA content in pregnant was significantly higher compared to non-pregnant (p < 0.001, 67.5%) and even in gestational diabetics; its value was found significantly further elevated (p = 0.001, 13.8%) compared to healthy pregnant. There was significant decline (p < 0.001, 41.9%) in the level of vitamin C in pregnant as compared to non-pregnant. Although in GDM the decrease was significant (p = 0.025, 20.6%) but comparatively lesser when compared to healthy pregnant. Vitamin E showed the increase of 9.6% during pregnancy, although this alteration was non-significant (p = 0.09), but the level was found to decline significantly (p < 0.001, 25.5%) in GDM compared to pregnant group. Vitamin A contents were also decreased in pregnant (p = 0.002, 17.4%) compared to non-pregnant and in GDM (p = 0.012, 11.2%) compared to pregnant group. Osmotic fragility (O.F.) profiles showed insignificant (p = 0.325) enhanced mean erythrocyte fragility (MEF) in pregnant but this increase was significant (p = 0.003) in case of GDM. The O.F. profiles of pregnant and GDM erythrocytes got shifted to the right side of the control one.Conclusions:?Our findings indicate highly enhanced lipid peroxidation and significant depletion in antioxidant capacity during the development of gestational diabetes, and these alterations are not the cause but the consequence of GDM. However, further studies are warranted to examine a wider range of biochemical parameters to evaluate the potential risks of oxidative damage in GDM.doi:10.4021/jocmr454w
机译：背景：关于妊娠糖尿病发病过程中的氧化状态和抗氧化能力的文献报道不一致。本研究旨在评估妊娠糖尿病发展过程中的氧化应激，并评估非妊娠（对照），妊娠和妊娠糖尿病患者的抗氧化能力。方法：本研究由非妊娠，健康孕妇和妊娠糖尿病患者组成。 （GDM）。每个小组由23名妇女组成。我们比较了它们在血液中的氧化和抗氧化系统。测定他们的血液丙二醛（MDA）和抗氧化剂维生素（C，E，A）并进行比较，以评估这些组的氧化状态和抗氧化能力。我们还比较了这些组的红细胞的渗透脆性。结果：孕妇血浆MDA含量明显高于非孕妇（p <0.001，67.5％），甚至是妊娠糖尿病患者。与健康孕妇相比，其价值被发现进一步显着提高（p = 0.001，13.8％）。与未怀孕相比，孕妇的维生素C水平显着下降（p <0.001，41.9％）。尽管在GDM中下降显着（p = 0.025，20.6％），但与健康孕妇相比下降幅度较小。维生素E在妊娠期间显示增加了9.6％，尽管这种变化无统计学意义（p = 0.09），但发现与妊娠组相比，GDM中的维生素E水平显着下降（p <0.001，25.5％）。与未怀孕组相比，孕妇中的维生素A含量也有所降低（p = 0.002，17.4％），而与妊娠组相比，GDM中维生素A含量（p = 0.012，11.2％）也降低了。渗透脆性（O.F.）曲线显示孕妇的平均红细胞脆性（MEF）增强不明显（p = 0.325），但是对于GDM而言，这种增加是显着的（p = 0.003）。 O.F.结论：我们的发现表明，在妊娠糖尿病的发展过程中，脂质过氧化作用大大增强，抗氧化能力显着降低，这些改变不是原因，而是后果。 GDM。但是，有必要进行进一步的研究，以检查更广泛的生化参数，以评估GDM中氧化损伤的潜在风险。doi：10.4021 / jocmr454w

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