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首页> 外文期刊>Journal of Clinical Medicine Research >The Relationship Between Mean Platelet Volume and Fasting Plasma Glucose and HbA1c Levels in a Large Cohort of Unselected Health Check-Up Participants
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The Relationship Between Mean Platelet Volume and Fasting Plasma Glucose and HbA1c Levels in a Large Cohort of Unselected Health Check-Up Participants

机译：大量未选健康检查参与者的平均血小板体积与空腹血浆葡萄糖和HbA1c水平之间的关系

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Background: Larger platelets are more active and mean platelet volume (MPV) is an indicator of platelet activation and an independent risk factor of cardiovascular diseases. While MPV is reported to be higher in diabetic patients, the relationship between MPV and glycemic parameters in general population remains inconclusive.Methods: In this cross-sectional study, we studied relationship between MPV and fasting plasma glucose (FPG) and HbA1c levels in 38,204 unselected participants of general health check-up aged 20 years or older in the year of 2014 who were considered to be representative of the general population. Individuals with known diabetes, coronary artery disease and/or cerebrovascular disease who were on drug therapy and those with platelet counts below 100 × 109/L or above 400 × 109/L were excluded.Results: The mean age of the individuals was 52.3 ± 12.1 years and 46.1% were male. There were positive associations between MPV and both FPG (r = 0.066; P < 0.001) and HbA1c (r = 0.025; P < 0.001) levels when all individuals were analyzed as a whole. While the association was only marginal in individuals with HbA1c levels below 6.5% (r = 0.009; P = 0.068), it was significant in those with HbA1c ≥ 6.5% (r = 0.138; P < 0.001). When the individuals were categorized into four groups according to the HbA1c values: HbA1c < 5.5%, 5.5% ≤ HbA1c < 6.0%, 6.0% ≤ HbA1c < 6.5%, and HbA1c ≥ 6.5%, the mean MPV was virtually same among groups with HbA1c level < 6.5% and that of the individuals with HbA1c ≥ 6.5 was significantly higher than groups with lower HbA1c levels. Multivariate analyses adjusted with age and sex showed the same results.Conclusion: FPG and HbA1c appeared to be associated with MPV in unselected health check-up participants; however, the association between glycemic state and MPV was apparent only in individuals with impaired glycemic control and only marginal in those with normal glycemic control. The clinical significance of the associations warrants further study.J Clin Med Res. 2018;10(4):345-350doi: https://doi.org/10.14740/jocmr3361w.
机译：背景：较大的血小板更活跃，平均血小板体积（MPV）是血小板活化的指标，是心血管疾病的独立危险因素。尽管据报道糖尿病患者的MPV较高，但一般人群中MPV与血糖参数之间的关系尚无定论。方法：在本横断面研究中，我们研究了38,204中MPV与空腹血糖（FPG）和HbA1c水平之间的关系。 2014年年龄在20岁或20岁以上的一般健康检查未选参与者，被认为是一般人群的代表。排除了接受药物治疗的已知糖尿病，冠状动脉疾病和/或脑血管疾病患者以及血小板计数低于100×109 / L或高于400×109 / L的患者。结果：这些人的平均年龄为52.3±男性为12.1岁，占46.1％。当对所有个体进行整体分析时，MPV与FPG（r = 0.066; P <0.001）和HbA1c（r = 0.025; P <0.001）水平呈正相关。虽然该关联仅在HbA1c水平低于6.5％（r = 0.009; P = 0.068）的个体中是边缘性的，但在HbA1c≥6.5％（r = 0.138; P <0.001）的个体中是显着的。根据HbA1c值将个体分为四组：HbA1c <5.5％，5.5％≤HbA1c <6.0％，6.0％≤HbA1c <6.5％和HbA1c≥6.5％，MPV平均值在各组之间基本相同HbA1c水平<6.5％和HbA1c≥6.5的个体显着高于HbA1c水平较低的组。结论：FPG和HbA1c似乎与未选择的健康检查参与者的MPV相关;结果显示，FPG和HbA1c似乎与MPV相关。然而，只有在血糖控制受损的人中，血糖状态和MPV之间的关联才明显，而在血糖控制正常的人中，只有边缘的存在。该协会的临床意义值得进一步研究。JClin Med Res。 2018; 10（4）：345-350doi：https://doi.org/10.14740/jocmr3361w。

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