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首页> 外文期刊>Journal of Clinical Medicine Research >Trisomy 13 and Massive Fetomaternal Hemorrhage
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Trisomy 13 and Massive Fetomaternal Hemorrhage

机译：13三体综合征和大量胎儿期母体出血

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This is the first case report of trisomy 13 complicated by massive fetomaternal hemorrhage (FMH). A pale male infant weighing 2,950 g was delivered with low Apgar scores by emergency cesarean section due to non-reassuring fetal status. The umbilical arterial pH and hemoglobin level were 6.815 and 6.9 g/dL (normal: 13 - 22 g/dL), respectively. The maternal hemoglobin-F and serum alpha-fetoprotein levels were 6.0% (normal: < 1.0%) and 1,150 ng/mL (4.1 multiple of median), respectively. The neonate was diagnosed as having trisomy 13 by a subsequent chromosome examination. In the placenta, massive intervillous thrombosis was observed microscopically. This placental finding has been reported to be associated with both preeclampsia and massive FMH. In addition, the incidence of preeclampsia in pregnancies complicated by trisomy 13 has been reported to be significantly higher than normal karyotype populations. Therefore, the current finding may support the association between trisomy 13 and the incidence of massive FMH.J Clin Med Res. 2015;7(7):564-565doi: http://dx.doi.org/10.14740/jocmr2169w
机译：这是第13号三体综合征并发大量胎儿母亲出血（FMH）的首例病例报告。由于胎儿状况不安定，通过紧急剖腹产分娩出体重为2,950 g的苍白男婴，Apgar评分较低。脐动脉pH和血红蛋白水平分别为6.815和6.9 g / dL（正常值：13-22 g / dL）。孕妇的血红蛋白F和血清甲胎蛋白水平分别为6.0％（正常：<1.0％）和1,150 ng / mL（中位数的4.1倍）。通过随后的染色体检查，该新生儿被诊断为患有13三体性。在胎盘中，在显微镜下观察到大量的绒毛间血栓形成。据报道该胎盘发现与先兆子痫和大量FMH有关。此外，据报道，妊娠合并先兆子痫的发病率与三体性13相比，明显高于正常的核型人群。因此，目前的发现可能支持13三体性与大规模FMH的发生之间的关联。 2015; 7（7）：564-565doi：http://dx.doi.org/10.14740/jocmr2169w

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