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首页> 外文期刊>Journal of Clinical Medicine Research >Small Vessel Disease/White Matter Disease of the Brain and Its Association With Osteoporosis
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Small Vessel Disease/White Matter Disease of the Brain and Its Association With Osteoporosis

机译：脑小血管疾病/白质病及其与骨质疏松的关系

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Background: Evidence now suggests the role of neural effect on bone mass control. The effect of small vessel disease of the brain on osteoporosis has not been studied. The aim of this study was to investigate the association of white matter disease (WMD) of the brain with osteoporosis in the elderly.Methods: In this retrospective cross-sectional study, 780 consecutive patient charts between 2010 and 2011 were reviewed in the Senior’s Outpatient Clinic at the University of Alberta Hospital. Subjects with brain computerized tomography (CT) were included in the study. Subjects with incomplete information, intracranial hemorrhage, acute stroke, cerebral edema, and/or normal pressure hydrocephalus on the CT were excluded. WMD was quantified on CT using Wahlund’s scoring protocol. Osteoporosis information was obtained from the chart, which has been diagnosed based on bone mineral density (BMD) information. Logistic regression analysis was done to determine the association of WMD severity with osteoporosis after controlling for confounding vascular risk factors.Results: Of the 505 subjects who were included in the study, 188 (37%) had osteoporosis and 171 (91%) of these osteoporotic subjects were females. The mean age was 79.8 ± 7.04 years. The prevalence of WMD in osteoporosis subjects was 73%. In the unadjusted logistic regression analysis, there was a significant association between WMD severity and osteoporosis (odds ratio (OR): 1.10; 95% confidence interval (CI): 1.05 - 1.14; P < 0.001) and the significance remained in the adjusted model, after correcting for age, sex and all vascular risk factors (OR: 1.11; 95% CI: 1.05 - 1.18; P < 0.001).Conclusion: WMD severity of the brain was associated with osteoporosis in the elderly.J Clin Med Res. 2015;7(5):297-302doi: http://dx.doi.org/10.14740/jocmr2119w
机译：背景：现在有证据表明神经作用在骨量控制中的作用。尚未研究脑小血管疾病对骨质疏松症的影响。这项研究的目的是调查老年人的脑白质病（WMD）与骨质疏松的关系。方法：在这项回顾性横断面研究中，回顾了2010年至2011年间在老年人门诊部连续检查的780例患者病历艾伯塔大学医院诊所。这项研究包括具有脑部计算机断层扫描（CT）的受试者。排除CT信息不全，颅内出血，急性中风，脑水肿和/或正常压力脑积水的受试者。使用Wahlund评分方案在CT上对WMD进行了量化。从图表中获得了骨质疏松症信息，该信息已根据骨矿物质密度（BMD）信息进行了诊断。在控制混杂的血管危险因素后，进行了Logistic回归分析，确定了WMD严重程度与骨质疏松的关系。结果：纳入研究的505名受试者中，有188名（37％）患有骨质疏松，其中171名（91％）骨质疏松的受试者是女性。平均年龄为79.8±7.04岁。在骨质疏松症受试者中，WMD的患病率为73％。在未经调整的Logistic回归分析中，WMD严重程度与骨质疏松症之间存在显着相关性（优势比（OR）：1.10; 95％置信区间（CI）：1.05-1.14; P <0.001），并且显着性仍然存在于调整后的模型中校正年龄，性别和所有血管危险因素后（OR：1.11; 95％CI：1.05-1.18; P <0.001）。结论：老年人的脑部WMD严重程度与骨质疏松症有关.J Clin Med Res。 2015; 7（5）：297-302doi：http://dx.doi.org/10.14740/jocmr2119w

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