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首页> 外文期刊>Journal of Clinical & Translational Endocrinology >Role of omentin-1 and C-reactive protein in obese subjects with subclinical inflammation
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Role of omentin-1 and C-reactive protein in obese subjects with subclinical inflammation

机译：omentin-1和C反应蛋白在肥胖亚临床炎症患者中的作用

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BackgroundWhile chronic subclinical inflammation is now considered to be a predisposing risk factor of cardiovascular diseases, the extent by which adipokines induce metabolic abnormalities in humans is not fully resolved. The purpose of this study was to examine the relationship between insulin resistance and serum inflammatory markers in obese subjects.MethodsOne hundred and five subjects without any clinically evident CVD were classified into 3 coronary risk levels according to Framingham risk score. Demographic and anthropometric variables were estimated. Serum levels of lipid profile, blood glucose, insulin, omentin-1 and high sensitivity-C reactive protein (hs-CRP) were measured in fasting blood samples. Insulin resistance indices were also calculated.Results29% and 62% of the study population were overweight and obese respectively by body mass index (BMI) measures. Almost half of the study population was considered diabetic. There was a tendency for a fall in serum omentin-1 concentrations with increasing coronary risk with a significant increase in hs-CRP levels in the same direction (p?
机译：背景技术虽然现在认为慢性亚临床炎症是心血管疾病的诱发因素，但脂肪因子诱导人类代谢异常的程度尚未完全解决。这项研究的目的是检查肥胖患者的胰岛素抵抗与血清炎症标志物之间的关系。方法根据弗雷明汉风险评分，将一百零五名无任何临床上明显的CVD的患者分为3种冠心病危险等级。人口和人体测量变量被估计。在空腹血样中测量血清脂质水平，血糖，胰岛素，omentin-1和高敏感性C反应蛋白（hs-CRP）。结果还显示，按体重指数（BMI）衡量，分别有29％和62％的人超重和肥胖。几乎一半的研究人群被认为是糖尿病患者。在同一方向上，血清omentin-1浓度有降低的趋势，并伴随着冠状动脉危险的增加，同时hs-CRP水平也显着升高（p <0.05）。发现年龄和空腹血糖与血清omentin-1水平独立相关。 BMI和空腹血糖是血清hs-CRP水平的独立决定因素。结论Omentin-1可能通过胰岛素活性和肥胖与糖尿病的发展间接相关。通过进一步的纵向研究，这些发现可能对糖尿病的病理生理和治疗具有重要意义。

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