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首页> 外文期刊>Journal of Clinical & Translational Endocrinology >Impact of vitamin D status on statin-induced myopathy
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Impact of vitamin D status on statin-induced myopathy

机译：维生素D状态对他汀类药物引起的肌病的影响

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Highlights ? Vitamin D status plays an important role in the consideration of statin-induced myopathy. ? Correction of vitamin D deficiency (?20?ng/mL) can improve statin tolerance rates. ? Low vitamin D concentrations may be considered a modifiable risk factor for muscle-related adverse effects of statins. Abstract Introduction There is a multitude of evidence supporting the benefit of statin use in cardiovascular disease; however, statin-induced myopathy is a major reason for statin discontinuation and non-adherence. Vitamin D deficiency has been independently associated with muscle weakness and severe myopathy, and may be a confounder for statin-induced myopathies. Since there is no consensus on a treatment course of action for statin-induced myopathy, investigation into potential confounders to elucidate the dynamics of statin-induced myopathy is warranted. Methods A retrospective chart review was conducted on 105 patients in a cardiometabolic clinic with a vitamin D drawn from December 2006 to April 2008. Patients exposed to statins were divided into two groups: (1) patients with low vitamin D (32?ng/mL) [n?=?52] and (2) patients with a sufficient vitamin D level (?32?ng/mL) [n?=?32]. Data were compared via t-tests or Fisher’s Exact, as appropriate. Results There were 41 statin-specific myopathies amongst the 24 statin-intolerant patients. Low vitamin D was significantly associated with statin-induced myopathy (p?=?0.048). Following prescription vitamin D supplementation, statin tolerance rates were significantly higher in patients with a baseline vitamin D ?20?ng/mL than those with a baseline vitamin D 20?ng/mL (90% vs 33%; p?=?0.036). Conclusion Vitamin D status may be considered a modifiable risk factor for muscle-related adverse effects of statins, and supplementation of vitamin D (particularly when ?20?ng/mL) may improve statin tolerance.
机译：强调 ？维生素D的状态在考虑他汀类药物引起的肌病中起重要作用。 ？纠正维生素D缺乏症（？20？ng / mL）可以提高他汀类药物的耐受率。 ？低维生素D浓度可被认为是他汀类药物与肌肉相关的不良反应的可改变危险因素。摘要引言有大量证据支持他汀类药物在心血管疾病中的益处。但是，他汀类药物引起的肌病是他汀类药物停用和不依从的主要原因。维生素D缺乏症已与肌肉无力和严重的肌病独立相关，并且可能是他汀类药物引起的肌病的混杂因素。由于对于他汀类药物引起的肌病的治疗方法尚无共识，因此有必要调查潜在的混杂因素以阐明他汀类药物引起的肌病的动态。方法2006年12月至2008年4月在心脏代谢诊所对105例维生素D患者进行回顾性图表回顾。暴露于他汀类药物的患者分为两组：（1）维生素D低（<32？ng / （n）= [52]和（2）具有足够维生素D水平（？32？ng / mL）[n？=？32]的患者。适当时通过t检验或Fisher精确检验比较数据。结果24例他汀类药物不耐受患者中有41例他汀类药物特异性肌病。维生素D含量低与他汀类药物引起的肌病有显着相关性（p = 0.048）。补充维生素D后，基线维生素D≥20？ng / mL的患者的他汀类药物耐受率显着高于基线维生素D> 20？ng / mL的患者（90％比33％; p？=？0.036） ）。结论维生素D状态可能被认为是他汀类药物与肌肉相关的不良反应的可改变危险因素，补充维生素D（尤其是当≥20ng/ mL时）可以提高他汀类药物的耐受性。

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