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首页> 外文期刊>Journal of Clinical Medicine >Estimation of Arterial Carbon Dioxide Based on End-Tidal Gas Pressure and Oxygen Saturation
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Estimation of Arterial Carbon Dioxide Based on End-Tidal Gas Pressure and Oxygen Saturation

机译：基于潮气终压和氧饱和度的动脉二氧化碳估算

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Arterial blood gas (ABG) analysis is the traditional method for measuring the partial pressure of carbon dioxide. In mechanically ventilated patients a continuous noninvasive monitoring of carbon dioxide would obviously be attractive. In the current study, we present a novel formula for noninvasive estimation of arterial carbon dioxide. Eighty-one datasets were collected from 19 anesthetized and mechanically ventilated pigs. Eleven animals were mechanically ventilated without interventions. In the remaining eight pigs the partial pressure of carbon dioxide was manipulated. The new formula (Formula 1) is PaCO 2 = PETCO 2 + k(PETO 2 ? PaO 2 ) where PaO 2 was calculated from the oxygen saturation. We tested the agreements of this novel formula and compared it to a traditional method using the baseline PaCO 2 ? ETCO 2 gap added to subsequently measured, end-tidal carbon dioxide levels (Formula 2). The mean difference between PaCO 2 and calculated carbon dioxide (Formula 1) was 0.16 kPa (±SE 1.17). The mean difference between PaCO 2 and carbon dioxide with Formula 2 was 0.66 kPa (±SE 0.18). With a mixed linear model excluding cases with cardiorespiratory collapse, there was a significant difference between formulae ( p 0.001), as well as significant interaction between formulae and time ( p 0.001). In this preliminary animal study, this novel formula appears to have a reasonable agreement with PaCO 2 values measured with ABG analysis, but needs further validation in human patients.
机译：动脉血气（ABG）分析是测量二氧化碳分压的传统方法。在机械通气患者中，对二氧化碳进行连续无创监测显然很有吸引力。在当前的研究中，我们提出了一种新的公式，用于无创估计动脉二氧化碳。从19头麻醉的和机械通风的猪中收集了81个数据集。在没有干预的情况下，对11只动物进行了机械通气。在其余八头猪中，控制了二氧化碳的分压。新的式（式1）为PaCO 2 ＝ PETCO 2 + k（PETO 2≤PaO2），式中，PaO 2由氧饱和度算出。我们测试了该新颖配方的一致性，并将其与使用基线PaCO 2？的传统方法进行了比较。 ETCO 2缺口增加了随后测得的潮气末二氧化碳水平（公式2）。 PaCO 2与计算出的二氧化碳（公式1）之间的平均差为0.16 kPa（±SE 1.17）。 PaCO 2和具有式2的二氧化碳之间的平均差为0.66 kPa（±SE 0.18）。使用混合线性模型，排除心肺衰竭的病例，公式之间存在显着差异（p <0.001），公式与时间之间存在显着的交互作用（p <0.001）。在这项初步的动物研究中，该新配方似乎与通过ABG分析测得的PaCO 2值具有合理的一致性，但需要在人类患者中进行进一步验证。

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