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首页> 外文期刊>Journal of Clinical Medicine >Clinical and Rehabilitative Predictors of Peak Oxygen Uptake Following Cardiac Transplantation
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Clinical and Rehabilitative Predictors of Peak Oxygen Uptake Following Cardiac Transplantation

机译:心脏移植后峰值吸氧量的临床和康复预测指标

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The measurement of peak oxygen uptake (VO 2peak ) is an important metric for evaluating cardiac transplantation (HTx) eligibility. However, it is unclear which factors (e.g., recipient demographics, clinical parameters, cardiac rehabilitation (CR) participation) influence VO 2peak following HTx. Consecutive HTx patients with cardiopulmonary exercise testing (CPET) between 2007–2016 were included. VO 2peak was measured from CPET standard protocol. Regression analyses determined predictors of the highest post-HTx VO 2peak (i.e., quartile 4: VO 2peak 20.1 mL/kg/min). One hundred-forty HTx patients (women: n = 41 (29%), age: 52 ± 12 years, body mass index (BMI): 27 ± 5 kg/m 2 ) were included. History of diabetes (Odds Ratio (OR): 0.17, 95% Confidence Interval (CI): 0.04–0.77, p = 0.021), history of dyslipidemia (OR: 0.42, 95% CI: 0.19–0.93, p = 0.032), BMI (OR: 0.90, 95% CI: 0.82–0.99, p = 0.022), hemoglobin (OR: 1.29, 95% CI: 1.04–1.61, p = 0.020), white blood cell count (OR: 0.81, 95% CI: 0.66–0.98, p = 0.033), CR exercise sessions (OR: 1.10, 95% CI: 1.04–1.15, p 0.001), and pre-HTx VO 2peak (OR: 1.17, 95% CI: 1.07–1.29, p = 0.001) were significant predictors. Multivariate analysis showed CR exercise sessions (OR: 1.10, 95% CI: 1.03–1.16, p = 0.002), and pre-HTx VO 2peak (OR: 1.16, 95% CI: 1.04–1.30, p = 0.007) were independently predictive of higher post-HTx VO 2peak . Pre-HTx VO 2peak and CR exercise sessions are predictive of a greater VO 2peak following HTx. These data highlight the importance of CR exercise session attendance and pre-HTx fitness in predicting VO 2peak post-HTx.
机译:峰值摄氧量(VO 2peak)的测量是评估心脏移植(HTx)资格的重要指标。但是,目前尚不清楚哪些因素(例如,接受者的人口统计学,临床参数,心脏康复(CR)参与)会影响HTx后的VO 2peak。纳入2007–2016年间连续进行HTx并进行心肺运动测试(CPET)的患者。 VO 2peak是根据CPET标准协议测得的。回归分析确定了最高HTx后VO 2peak的预测指标(即四分位数4:VO 2peak> 20.1 mL / kg / min)。包括一百四十名HTx患者(妇女:n = 41(29%),年龄:52±12岁,体重指数(BMI):27±5 kg / m 2)。糖尿病病史(几率(OR):0.17,95%置信区间(CI):0.04-0.77,p = 0.021),血脂异常病史(OR:0.42,95%CI:0.19-0.93,p = 0.032), BMI(OR:0.90,95%CI:0.82–0.99,p = 0.022),血红蛋白(OR:1.29,95%CI:1.04–1.61,p = 0.020),白细胞计数(OR:0.81,95%CI :0.66-0.98,p = 0.033),CR运动(OR:1.10、95%CI:1.04-1.15,p <0.001)和HTx VO 2peak之前(OR:1.17、95%CI:1.07-1.29, p = 0.001)是重要的预测指标。多变量分析显示CR锻炼时间(OR:1.10,95%CI:1.03-1.16,p = 0.002)和HTx前VO 2peak(OR:1.16,95%CI:1.04-1.30,p = 0.007)是独立预测的HTx VO 2peak之后的值。 HTx之前的VO 2peak和CR运动训练可以预测HTx之后会有更大的VO 2peak。这些数据突显了CR运动会议出席率和HTx前适应度对预测HTx后VO 2peak的重要性。

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