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首页> 外文期刊>Journal of Clinical Medicine and Research >Enterovirus outbreak among preterm infants in Singapore General Hospital: Level II nursery Tan, Mary Grace S. and Yeo, Cheo Lian
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Enterovirus outbreak among preterm infants in Singapore General Hospital: Level II nursery Tan, Mary Grace S. and Yeo, Cheo Lian

机译：新加坡综合医院早产儿肠病毒暴发：谭（Tan），玛丽·格蕾丝（Mary Grace S.）和叶廉（Cheo Lian）二级医院

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摘要

To describe the demographic characteristics, clinical presentations and outcome of neonatal enterovirus infection and to evaluate infection control measures effective in preventing the spread of infection. Detailed perinatal history, demography, neonatal conditions and laboratory investigations were retrieved retrospectively from 5 Enterovirus positive patients in the level II nursery of the Singapore General Hospital in October 2010. Five premature neonates tested positive for Enterovirus during the outbreak. All infected neonates presented with lethargy, 4 (80%) poor suck, 4 (80%) apnea, 2 (40%) poor perfusion and 1 (20%) had pyrexia. Enterovirus was positive on PCR analysis of the stool specimen in four infected neonates and on spinal fluid in one neonate. All infected neonates required respiratory support; 3 needed?continuous positive airway pressure (CPAP), one required SIPPV and another needed HFOV. Inotropes was needed in 1(20%) infant and severe thrombocytopenia was documented in 3 infected neonates. The neonate who required?High frequency oscillatory ventilation?(HFOV) and inotropic support died on day 5 of illness. Four (80%) neonates recovered 5 days following the onset of illness. Neonatal enterovirus infection can lead to morbidity and even death. Pertinent history of exposure, early recognition, timely intervention and appropriate infection control measures are necessary to prevent dissemination of infection.
机译：描述新生儿肠病毒感染的人口统计学特征，临床表现和结果，并评估可有效预防感染扩散的感染控制措施。回顾性地回顾了2010年10月在新加坡总医院II级托儿所中5例肠病毒阳性患者的围产期历史，人口统计学，新生儿情况和实验室检查。在暴发期间，有5例早产儿肠病毒呈阳性。所有感染的新生儿表现为嗜睡，4（80％）吸吮不良，4（80％）呼吸暂停，2（40％）灌注不良和1（20％）发热。肠道病毒对4名被感染新生儿的粪便样本进行PCR分析呈阳性，而1名新生儿的脊髓液呈阳性。所有感染的新生儿都需要呼吸支持;需要3个持续气道正压（CPAP），一个需要SIPPV，另一个需要HFOV。 1（20％）婴儿需要正性肌力药，3例感染的新生儿有严重的血小板减少症。需要高频振荡通气（HFOV）和正性肌力支持的新生儿在患病的第5天死亡。发病后5天有4名（80％）新生儿康复。新生儿肠病毒感染可导致发病甚至死亡。相关的接触史，及早识别，及时干预和适当的感染控制措施对于防止感染传播是必要的。

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