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首页> 外文期刊>Journal of Clinical Medicine and Research >Combined oral and vaginal misoprostol use in therapeutic terminations at 14 to 28 weeks of gestation
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Combined oral and vaginal misoprostol use in therapeutic terminations at 14 to 28 weeks of gestation

机译：在妊娠14至28周时终止口服和阴道米索前列醇联合治疗终止治疗

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This study involved an investigation of the effectiveness and complications of oral and vaginal misoprostol use on the termination of second trimester pregnancies. A total of 103 cases were recruited from the medical records of the Gynecology and Obstetrics Clinic of Taksim Research and Training Hospital and ??rnak ?dil State Hospital. Women underwent therapeutic termination of pregnancy between the?14 to 28th week?of gestation using the defined combined misoprostol regimen. After the women were admitted, 200 μg vaginal (100 μg intracervical, 100 μg into the posterior fornix), 200 μg oral doses and 200 μg of sequential doses were administered in the 2nd and 4th hour. Subjects were excluded from the study if they were out of the defined gestational weeks using additional drugs with misoprostol; their data has not been recorded in detail. Of the 103 cases, 86 had an abortion within 24 h and the mean expulsion time was calculated as 15.42?±?7.14 h (min 6.39 to max 20.03) in this group. The success rate for the 24 h was found to be 83.4%. Six more cases had an abortion when the second dose was given. The mean expulsion time was found to be 9.31?±?3.26 h (min 6.45 to max 13.21) for the second 24 h. The success rate over 48 h rose to 89.3%. The total expulsion time was 18.30?±?8.74 h. There was a history of previous caesarean sections in 2 out of 11 cases that did not have an abortion and one of these cases underwent a hysterotomy. The pregnancy was terminated by evacuation and curettage, as abortion did not occur despite 3 different high dose misoprostol regimens as in the other cases. Pregnancies of the remaining 9 cases were terminated with different misoprostol doses, oxytocin infusion and the evacuation and curettage method. When complication rates were evaluated, analgesic requiring pain (18.4%) was the leading complication, followed by nausea (11.6%), fever (7.7%), headaches and dizziness (5.8%), transfusion-requiring haemorrhage (3.8%) and diarrhea (1.9%). Uterine rupture or death did not occur. A combined misoprostol regimen is relatively safe with acceptable side effects when used carefully for the termination of second trimester pregnancies.?Keyword: Misoprostol, Pregnancy Trimester. Second, Termination of Pregnancy, Mean Expulsion Time, Medical Termination, Vacuum Curettage, Side Effects.
机译：这项研究涉及对妊娠中期妊娠终止使用口服和阴道米索前列醇的有效性和并发症的调查。从塔克西姆研究训练医院和纳克菲迪尔州立医院的妇产科诊所的病历中招募了103例病例。使用定义的米索前列醇联合治疗方案，妇女在妊娠的第14至28周之间接受了治疗性终止妊娠。入院后，在第2和第4个小时分别给予200μg阴道（100μg腹腔内，100μg进入后穹ni），200μg口服剂量和200μg连续剂量。如果受试者在确定的孕周内未使用其他米索前列醇药物，则被排除在研究之外;他们的数据尚未详细记录。在这103例病例中，有86例在24小时内流产，平均驱除时间为15.42±7.14小时（最小6.39至最大20.03）。发现24小时的成功率为83.4％。第二次注射后又有六例流产。第二个24小时的平均驱逐时间为9.31±3.26小时（最小6.45至最大13.21）。在48小时内成功率升至89.3％。总排出时间为18.30±8.74小时。在11例没有流产的病例中，有2例曾做过剖腹产手术，其中1例接受了子宫切开术。妊娠由于疏散和刮宫而终止，因为尽管与其他情况一样，尽管有3种不同的高剂量米索前列醇方案也没有发生流产。其余9例孕妇均以不同剂量的米索前列醇剂量，催产素输注以及疏散刮宫方法终止妊娠。在评估并发症发生率时，主要的并发症是需要止痛的镇痛药（18.4％），其次是恶心（11.6％），发烧（7.7％），头痛和头晕（5.8％），需要输血的出血（3.8％）和腹泻。 （1.9％）。没有发生子宫破裂或死亡。当联合使用米索前列醇方案用于终止中期妊娠时，是相对安全的且具有可接受的副作用。关键词：米索前列醇，妊娠中期其次，怀孕终止，平均驱逐时间，医疗终止，真空刮宫，副作用。

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