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首页> 外文期刊>Journal of Clinical Medicine and Research >Revealing the effect of probiotic combination: Lactobacillus rhamnosus and Lactobacillus acidophilus (Lacidofil) on acute diarrhea in adult patients
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Revealing the effect of probiotic combination: Lactobacillus rhamnosus and Lactobacillus acidophilus (Lacidofil) on acute diarrhea in adult patients

机译：揭示益生菌组合：鼠李糖乳杆菌和嗜酸乳杆菌（Lacidofil）对成年患者急性腹泻的作用

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The concept of taking probiotic supplementation for better health and improving acute episodes of diarrhea has been well-known. Several studies have indicated that probiotic supplementation bring beneficial effects for patients with diarrhea. However, there is a striking lack of evidence on the supplementation of probiotic products in adult patients with acute diarrhea and prescribing probiotics for acute diarrhea has been underestimated. A prospective, double-blind, randomized, controlled clinical trial was conducted in adult patients who visited the study sites at three hospitals (Cipto Mangunkusumo, Koja and Tarakan Hospital) in Jakarta between 2007 and 2010. The subjects were divided into 2 groups, that is, the treatment group receiving?Lactobacillusspp. product?at the dose of 3 × 2 capsules for 7 days and the control group receiving placebo. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) software program. The p value of < 0.05 was considered significant. The study demonstrated a significant result of faster recovery from diarrhea 1.02 ± 0.48 days sooner than the placebo group (p = 0.018). Greater improvement on clinical outcomes (frequency of stools, stool consistency, abdominal pain, nausea, vomiting, bloating, headache, fever and tenesmus) were observed in the group receivingLactobacillus?spp. supplementation; however, the result was statistically significant on stool consistency only. Combined probiotic supplementation appears to be a promising therapeutic agent for treatment of acute diarrhea in adults. However, further controlled clinical studies as well as good storage, handling and distribution is essential to explore the therapeutic benefit for possible practical clinical application.
机译：服用益生菌补充剂以改善健康和改善腹泻的急性发作的概念是众所周知的。几项研究表明，补充益生菌可为腹泻患者带来有益的影响。然而，关于在成年急性腹泻患者中补充益生菌产品的证据十分缺乏，而针对急性腹泻开出益生菌的处方被低估了。对成年患者进行了一项前瞻性，双盲，随机对照临床研究，该患者于2007年至2010年期间在雅加达的三家医院（Cipto Mangunkusumo，Koja和Tarakan医院）访问了研究地点。受试者分为两组，即是，治疗组接受的是乳酸杆菌。剂量为3×2胶囊，共7天，对照组接受安慰剂。使用社会科学统计软件包（SPSS）软件程序进行统计分析。 p值<0.05被认为是显着的。该研究显示出比安慰剂组更快地从腹泻中恢复的更快的结果1.02±0.48天（p = 0.018）。在接受乳酸杆菌属的人群中，临床结果（大便次数，大便稠度，腹痛，恶心，呕吐，腹胀，头痛，发烧和里急后重）的改善更大。补充;但是，该结果仅在粪便稠度上具有统计学意义。组合益生菌补充剂似乎是用于治疗成人急性腹泻的有前途的治疗剂。然而，进一步的临床研究以及良好的储存，处理和分配对于探索可能的实际临床应用的治疗益处至关重要。

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