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首页> 外文期刊>Journal of Clinical Medicine Research >Rapid Hemodynamic Deterioration and Death due to Acute Severe Refractory Septic Shock
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Rapid Hemodynamic Deterioration and Death due to Acute Severe Refractory Septic Shock

机译：急性重度难治性脓毒性休克引起的血液动力学迅速恶化和死亡

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Despite emergence of early goal directed therapy, septic shock still carries a high mortality. Gram negative septicemia is notorious for rapid deterioration due to endotoxin release. Multi-organ damage due to septic shock carries poor prognosis, and such patients should be managed aggressively with multidisciplinary approach. We present a fatal case of a patient with gram negative septicemia who rapidly deteriorated, and died due to acute refractory severe septic shock. This patient probably developed urosepsis secondary to severe urinary tract infection. He also had infiltrates on chest radiograph. He expired within fifteen hours of presenting to the emergency department. This case emphasizes the importance of early recognition and management of septic shock. Early goal directed therapy has shown to improve mortality. Broad spectrum antibiotics should be started within one hour depending on local immunity of organisms. This case also highlights the fact that despite optimized treatment, this entity has very high mortality rates.?doi:10.4021/jocmr2009.04.1238Publication ahead of print May 25, 2009
机译：尽管出现了早期的靶向治疗，但败血性休克仍然具有很高的死亡率。众所周知，革兰氏阴性败血病会由于内毒素释放而迅速恶化。败血性休克引起的多器官损害预后较差，应采用多学科方法积极治疗此类患者。我们呈现了致命的革兰氏阴性败血症患者的案例，该患者迅速恶化，并因急性难治性严重败血症性休克死亡。该患者可能是继发于严重尿路感染的尿毒症患者。他的胸部X光片也有浸润。他在向急诊科求诊的十五小时内过期。该案例强调了败血性休克早期识别和处理的重要性。早期目标导向疗法已显示可提高死亡率。应根据生物体的局部免疫力，在一小时内开始使用广谱抗生素。该案例还凸显了这样一个事实，即尽管进行了优化治疗，该实体的死亡率仍然很高。doi：10.4021 / jocmr2009.04.1238印刷前的出版物2009年5月25日

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