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首页> 外文期刊>Journal of Clinical Medicine Research >The effect of ongoing vitamin D and low-fat milk intake on bone metabolism in female high-school endurance runners
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The effect of ongoing vitamin D and low-fat milk intake on bone metabolism in female high-school endurance runners

机译：正在进行的维生素D和低脂牛奶摄入对女高中耐力跑步运动员骨骼代谢的影响

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Background: Vitamin D and calcium are essential nutrients for bone health. In addition, vitamin D suppresses inflammatory cytokines and increases bone resorption. Therefore, improvements in bone health by calcium and vitamin D supplementation have the potential to not only improve calcium metabolism but also suppress inflammation associated with exercise training. The purpose of this study was to determine whether ongoing vitamin D supplementation and low-fat milk intake by female high-school endurance runners would improve bone metabolism by suppressing inflammatory cytokines and the parathyroid hormone (PTH).Methods: Twenty female high-school runners were assigned to a vitamin D supplement and low-fat milk intake group (MKD) or a control group (CON). Participants in the MKD group consumed a vitamin D supplement (1,000 IU/day) and low-fat milk (Ca 315 mg/day) for 6 months. Bone mineral density measurements, blood samples, and questionnaires (regarding menses and diet) were carried out. The UMIN Clinical Trials Registry number is UMIN000027854.Results: The 25-hydroxyvitamin D (25(OH)D) concentration in MKD was sustained and PTH concentration was decreased regardless of the state of menses. The correlation coefficients of 25(OH)D or PTH concentrations and bone metabolism markers were analyzed by partial correlation coefficient via adjusting the model for frequency of menses. CTX and 25(OH)D concentration were significantly and inversely correlated at baseline (r = -0.61, P < 0.01), 3 months (r = -0.54, P = 0.02), and 6 months (r = -0.53, P = 0.02). CTX and PTH were significantly and positively correlated at 3 months (r = 0.63, P < 0.01) and 6 months (r = 0.52, P = 0.02). The bone alkaline phosphatase (BAP)/CTX ratio and 25(OH)D concentration were significantly and positively correlated at 3 months (r = 0.59, P = 0.01) and 6 months (r = 0.56, P = 0.01). The BAP/CTX ratio and PTH were significantly and inversely correlated at 3 months (r = -0.59, P = 0.01) and 6 months (r = -0.58, P < 0.01).Conclusions: This study suggested that vitamin D and low-fat milk supplementation improves bone metabolism by sustaining the 25(OH)D concentration and decreasing the PTH concentration in female high-school endurance runners regardless of the state of menses.J Clin Med Res. 2018;10(1):13-21doi: https://doi.org/10.14740/jocmr3209w
机译：背景：维生素D和钙是骨骼健康必不可少的营养素。此外，维生素D抑制炎症细胞因子并增加骨吸收。因此，通过补充钙和维生素D改善骨骼健康不仅有可能改善钙代谢，而且还可以抑制与运动训练有关的炎症。这项研究的目的是确定持续不断的维生素D补充和高中耐力跑步者的低脂牛奶摄入是否会通过抑制炎症细胞因子和甲状旁腺激素（PTH）来改善骨骼代谢。方法：20名女性高中跑步者被分为维生素D补充剂和低脂牛奶摄入组（MKD）或对照组（CON）。 MKD组的参与者服用维生素D补充剂（1,000 IU /天）和低脂牛奶（钙315 mg /天）达6个月。进行了骨矿物质密度测量，血液样本和问卷（关于月经和饮食）。 UMIN临床试验注册号为UMIN000027854。结果：无论月经状态如何，MKD中的25-羟基维生素D（25（OH）D）浓度均保持不变，PTH浓度降低。通过调整月经频率模型，通过偏相关系数分析25（OH）D或PTH浓度与骨代谢指标的相关系数。 CTX和25（OH）D浓度在基线（r = -0.61，P <0.01），3个月（r = -0.54，P = 0.02）和6个月（r = -0.53，P = 0.02）。 CTX和PTH在3个月（r = 0.63，P <0.01）和6个月（r = 0.52，P = 0.02）呈显着正相关。骨碱性磷酸酶（BAP）/ CTX比和25（OH）D浓度在3个月（r = 0.59，P = 0.01）和6个月（r = 0.56，P = 0.01）时呈显着正相关。 BAP / CTX比值和PTH在3个月（r = -0.59，P = 0.01）和6个月（r = -0.58，P <0.01）时呈显着负相关。结论：这项研究表明维生素D和低维生素B不论月经状态如何，补充脂肪乳均可通过维持高中耐力跑者的25（OH）D浓度并降低PTH浓度来改善骨骼代谢。JClin Med Res。 2018; 10（1）：13-21doi：https://doi.org/10.14740/jocmr3209w

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