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首页> 外文期刊>Journal of Clinical Medicine Research >Quality Evaluation of Cone Biopsy Specimens Obtained by Large Loop Excision of the Transformation Zone
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Quality Evaluation of Cone Biopsy Specimens Obtained by Large Loop Excision of the Transformation Zone

机译：转换区大环切除术获得的锥形活检标本的质量评估

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Background: Large loop excision of the transformation zone (LLETZ) has been used for the diagnosis and treatment of precancerous cervical lesions, and it is the first choice of treatment in the majority of cervical pathology services. The aim of this study was to evaluate the presence of thermal artifacts, the need for serial sections, the percentage of clear and involved resection margins and the relationship between endocervical gland involvement and the severity of the lesion in samples resected using LLETZ.Methods: A retrospective study was performed at Santa Casa de Misericordia School of Science (HSCMV), Vitoria, Espirito Santo, Brazil with a sample of 52 histopathology slides from patients submitted to conization because of abnormal cytology findings and a biopsy result of cervical intraepithelial neoplasia (CIN) 2, CIN 3 and adenocarcinoma in situ. Statistical analysis was performed using Student’s t-test.Results: Serial sections were required to confirm diagnosis in four of 52 cases. Thermal artifacts were present in all cases, with grade I being the most common (94.2% of cases). Clear margins were found in 96.2% of cases. No association was found between glandular involvement and CIN 1 (P > 0.05); however, there was an association with CIN 2 and CIN 3 (P < 0.05).Conclusion: The amount of excised tissue was sufficient, thermal artifacts were slight, resection margins were clear in most of cases, and a possible association was found between glandular involvement and the severity of the lesion.J Clin Med Res. 2015;7(4):220-224doi: http://dx.doi.org/10.14740/jocmr1951w
机译：背景：转化区大环切除术（LLETZ）已用于诊断和治疗癌前宫颈病变，并且它是大多数宫颈病理服务中的首选治疗方法。这项研究的目的是评估使用LLETZ切除的样本中热伪影的存在，连续切片的必要性，清除切缘和累及切除切缘的百分比以及宫颈内膜受累与病变严重程度之间的关系。回顾性研究是在巴西圣埃斯皮里图（Espirito Santo）维多利亚市的圣卡萨德米西里科迪亚科学学校（HSCMV）进行的，样本中有52份组织病理学玻片的样本，这些玻片是由于细胞学检查结果异常和宫颈上皮内瘤变（CIN）的活检结果而被提交锥切术的2，CIN 3与原位腺癌。结果：在52例病例中有4例需要进行连续切片以确诊。在所有情况下均存在热伪影，其中I级最为常见（94.2％的情况）。在96.2％的案例中发现了明显的空白。未发现腺体受累与CIN 1相关（P> 0.05）;结论：切除的组织量足够，热伪影较小，切除切缘清晰，在大多数情况下，腺体之间可能存在相关性（P <0.05）。病变的受累程度和严重程度.J Clin Med Res。 2015; 7（4）：220-224doi：http://dx.doi.org/10.14740/jocmr1951w

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