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首页> 外文期刊>Journal of Clinical & Translational Endocrinology >Prevalence of diabetic nephropathy in Type 2 Diabetes Mellitus in rural communities of Guanajuato, Mexico. Effect after 6 months of Telmisartan treatment
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Prevalence of diabetic nephropathy in Type 2 Diabetes Mellitus in rural communities of Guanajuato, Mexico. Effect after 6 months of Telmisartan treatment

机译：墨西哥瓜纳华托州农村社区中2型糖尿病的糖尿病肾病患病率。替米沙坦治疗6个月后的疗效

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Highlights ? Diabetic Nephropathy prevalence was determined in Mexican rural communities. ? We evaluated ARB treatment over 6 months in patients with Diabetic Nephropathy. ? We found a higher prevalence of DN than reported in Mexican National Health Survey. ? Subjects receiving ARB showed significant improvement in all parameters studied. Abstract Objective To determine the prevalence of Diabetic Nephropathy (DN) in patients with type 2 Diabetes Mellitus (T2DM) with over 5 years of evolution in rural communities of Guanajuato, Mexico, and evaluate the effects of an ARB treatment over 6 months in patients with DN. Materials and methods Patients of both sexes, 38–86 years, T2DM over 5 years of evolution and diagnosed with arterial hypertension (HT) after T2DM incidence. Monthly determination of microalbuminuria (MA), lipids, glucose, serum creatinine, and glycated hemoglobin (HbA1c). Estimated glomerular filtration rate (eGFR) by the Modification of Diet in Renal Disease (MDRD) formula. A dose of 80?mg of Telmisartan was administered daily over 6 months. Results The total adult population of two rural communities (3609 subjects) was studied, 335 subjects had T2DM, among them 80 (with a prevalence of 24%) had DN and HT. Sixty-seven patients received Telmisartan, and showed significant improvement in all parameters studied. Conclusions A higher prevalence of DN than that reported in the Mexican National Health Survey (ENSANUT) was found. Further research is required in a larger population sample in order to confirm the results of Telmisartan treatment.
机译：强调 ？在墨西哥农村社区确定了糖尿病肾病患病率。 ？我们评估了糖尿病肾病患者6个月以上的ARB治疗。 ？我们发现DN的患病率比墨西哥国家健康调查中报告的要高。 ？接受ARB的受试者在所有研究的参数上均表现出明显改善。摘要目的确定在墨西哥瓜纳华托州农村社区发展超过5年的2型糖尿病（T2DM）患者的糖尿病肾病（DN）患病率，并评估ARB治疗6个月以上的糖尿病患者的疗效DN。材料和方法年龄在38-86岁之间的T2DM患者，经过5年的发展，并在T2DM发病后被诊断患有动脉高压（HT）。每月测定微量白蛋白尿（MA），脂质，葡萄糖，血清肌酐和糖化血红蛋白（HbA1c）。通过修改肾脏疾病饮食（MDRD）公式估算的肾小球滤过率（eGFR）。在六个月内每天服用80毫克替米沙坦。结果研究了两个农村社区的成人总人数（3609名受试者），其中335名患有2型糖尿病的受试者，其中80名（患病率24％）患有DN和HT。 67名患者接受了替米沙坦治疗，并且所有研究参数均显示出明显改善。结论发现的DN患病率比墨西哥国家健康调查（ENSANUT）报告的要高。为了确定替米沙坦治疗的结果，需要在更大的人群样本中进行进一步的研究。

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