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首页> 外文期刊>Journal of Clinical Medicine Research >Visit-to-Visit Variability and Seasonal Variation in Blood Pressure With Single-Pill Fixed-Dose Combinations of Angiotensin II Receptor Blocker/Calcium Channel Blocker and Angiotensin II Receptor Blocker/Diuretic in Hypertensive Patients
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Visit-to-Visit Variability and Seasonal Variation in Blood Pressure With Single-Pill Fixed-Dose Combinations of Angiotensin II Receptor Blocker/Calcium Channel Blocker and Angiotensin II Receptor Blocker/Diuretic in Hypertensive Patients

机译：高血压患者单药固定剂量联合使用血管紧张素II受体阻滞剂/钙通道阻滞剂和血管紧张素II受体阻滞剂/利​​尿剂的单次固定剂量就诊访视变异性和血压季节性变化

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Background: The visit-to-visit variability in blood pressure (BP) has been shown to be a strong predictor of cardiovascular events. It is not known whether anti-hypertensive therapy using a single-pill fixed-dose combination of angiotensin II receptor blocker (ARB)/calcium channel blocker (CCB) or ARB/diuretic (DI) in hypertensive patients affects the visit-to-visit variability and seasonal variation of BP.Methods: We enrolled 47 hypertensive patients who had received a single-pill fixed-dose combination of either ARB/CCB (n = 30) or ARB/DI (n = 17) for 15 months. Beginning 3 months after the start of ARB/CCB or ARB/DI treatment, we determined the visit-to-visit variability in BP expressed as the standard deviation (SD) of average BP and the seasonal variation in BP expressed as the SD of average BP in each season (spring, summer, fall and winter were defined as lasting from March to May, June to August, September to November and December to February, respectively) for a year.Results: There were no significant differences in baseline patient characteristics except for the prevalence of coronary artery disease and the percentage of CCB excluding amlodipine in the ARB/CCB group between the ARB/CCB and ARB/DI groups. There were no significant differences in the 1-year time course of systolic and diastolic BP (SBP and DBP) between the groups, although there were significant differences in SBP in August and November and DBP in December. Interestingly, the visit-to-visit variability and seasonal variation of BP in the ARB/CCB group were similar to those in the ARB/DI group.Conclusion: Single-pill fixed-dose combinations of ARB/CCB and ARB/DI had similar effects on visit-to-visit variability and seasonal variation in BP in hypertensive patients.J Clin Med Res. 2015;7(10):802-806doi: http://dx.doi.org/10.14740/jocmr2292w
机译：背景：血压（BP）的访视变异性是心血管事件的重要预测指标。尚不清楚在高血压患者中使用单药固定剂量的血管紧张素II受体阻滞剂（ARB）/钙通道阻滞剂（CCB）或ARB /利尿剂（DI）联合使用的抗高血压治疗是否会影响就诊方法：我们招募了47位接受ARB / CCB（n = 30）或ARB / DI（n = 17）单药固定剂量联合治疗的高血压患者15个月。在开始ARB / CCB或ARB / DI治疗后3个月开始，我们确定了BP的访视变异性，以平均BP的标准差（SD）表示，BP的季节性变化以平均SD的形式表示每个季节的BP（春季，夏季，秋季和冬季分别定义为3月至5月，6月至8月，9月至11月和12月至2月）持续一年。结果：基线患者特征无显着差异在ARB / CCB和ARB / DI组之间，除了冠状动脉疾病的患病率和ARB / CCB组中不包括氨氯地平的CCB百分比。两组之间的收缩压和舒张压BP（SBP和DBP）的1年时间进程无显着差异，尽管8月和11月的SBP和12月的DBP有显着差异。有趣的是，ARB / CCB组的BP访视变异性和季节性变化与ARB / DI组的相似。结论：ARB / CCB和ARB / DI的单药固定剂量组合具有相似的结果对高血压患者访视变异性和血压季节性变化的影响.J Clin Med Res。 2015; 7（10）：802-806doi：http://dx.doi.org/10.14740/jocmr2292w

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