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首页> 外文期刊>Journal of Clinical Medicine Research >The Association Between the Uncoupling Protein-1 Gene A-3826G Polymorphism and High-density Lipoprotein Cholesterol in A General Japanese Population: A Consideration of the Obesity Status
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The Association Between the Uncoupling Protein-1 Gene A-3826G Polymorphism and High-density Lipoprotein Cholesterol in A General Japanese Population: A Consideration of the Obesity Status

机译：日本普通人群中解偶联蛋白1基因A-3826G多态性与高密度脂蛋白胆固醇之间的关联：肥胖状况的考虑

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Background: Limited studies have shown inconsistent data about the association between the uncoupling protein 1 (UCP1) gene A-3826G polymorphism and high-density lipoprotein (HDL) cholesterol levels. The present study investigated the association between the A-3826G polymorphism and low HDL-cholesterolemia in non-obese and obese subjects.?Methods: Anthropometric and biochemical factors, in addition to genotyping by an allele-specific DNA assay, were measured in 294 community-dwelling Japanese subjects (male/female: 127/167, mean age: 65 years). Obesity was defined as a body mass index (BMI)?no less than?25 kg/m2, and low HDL-cholesterolemia was defined as?less than?1.04 mmol/L of HDL-cholesterol.?Results: The subjects with the G/G genotype (n = 27) showed a significantly higher prevalence of low HDL-cholesterolemia (37%) than those with the A/A + A/G genotype (13%) in the obese group (n = 102). There was a non-significant difference in the prevalence of low HDL-cholesterolemia between subjects with the G/G genotype (n = 45, 13%) and with the A/A + A/G genotype (15%) in the non-obese group (n = 192). A multivariate-adjusted logistic regression analysis of the presence of low HDL-cholesterolemia revealed that carrying the G/G genotype was an independent and significant factor positively associated with low HDL-cholesterolemia [CrossRef]odds ratio (OR): 6.85, 95% confidence interval (CI): 1.65-28.49] in the obese group, while carrying the G/G genotype exhibited a non-significant but reduced OR, by one-half, for low HDL-cholesterolemia (OR: 0.51, 95% CI: 0.13-1.96) in the non-obese group.?Conclusions: The obesity status could have opposing impacts on the relationship between the G/G genotype and low HDL-cholesterolemia, providing insight into the need to consider the obesity levels when studying the association between the UCP-1 gene A-3826G polymorphism and HDL-cholesterol.doi:10.4021/jocmr738w
机译：背景：有限的研究表明，有关解偶联蛋白1（UCP1）基因A-3826G多态性与高密度脂蛋白（HDL）胆固醇水平之间相关性的数据不一致。本研究调查了非肥胖和肥胖受试者中A-3826G多态性与低HDL胆固醇血症之间的关系。方法：在294个社区中，通过等位基因特异性DNA测定法对人体测量学和生化因素以及基因分型进行了测量。居住的日本人（男性/女性：127/167，平均年龄：65岁）。肥胖被定义为体重指数（BMI）≥25 kg / m2，低HDL-胆固醇血症被定义为HDL-胆固醇≤1.04mmol / L。结果：患有G的受试者/ G基因型（n = 27）显示低HDL-胆固醇血症（37％）的患病率显着高于肥胖组（n = 102）的A / A + A / G基因型（13％）。 G / G基因型（n = 45，13％）与A / A + A / G基因型（15％）之间，低HDL-胆固醇血症的患病率无显着差异。肥胖组（n = 192）。对低HDL胆固醇血症的存在进行的多因素校正logistic回归分析显示，携带G / G基因型是与HDL胆固醇低血症呈正相关的独立且重要因素[CrossRef]赔率（OR）：6.85，95％可信度肥胖组中区间（CI）：1.65-28.49]，对于低HDL-胆固醇血症，尽管携带G / G基因型，但无显着性，但OR降低了一半（OR：0.51，95％CI：0.13 -1.96）在非肥胖组中。结论：肥胖状况可能对G / G基因型与低HDL-胆固醇血症之间的关系产生相反的影响，从而提供了在研究肥胖与肥胖之间的关系时需要考虑肥胖程度的见解UCP-1基因A-3826G多态性和HDL-胆固醇.doi：10.4021 / jocmr738w

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