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首页> 外文期刊>Journal of Clinical and Experimental Investigations >The possible protective effect of melatonin on streptozotocin induced experimental diabetes
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The possible protective effect of melatonin on streptozotocin induced experimental diabetes

机译：褪黑素对链脲佐菌素诱发的实验性糖尿病的可能保护作用

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Objective: This experimental study aims to investigate the protective effect of melatonin on the enzymes’, which regulate glucose metabolism in liver tissue. Methods: In this experimental study, four-month-old male Wistar albino rats were used. The rats were divided into 4 groups as 7 rats in each group. Rats were grouped as control group, diabetic group, melatonin protecting group, as well as melatonin treatment group. Before the streptozotocin implementation to melatonin protecting group (seven days ago) everyday at 18.00 melatonin was implemented for seven days. On the other hand melatonin was implemented to melatonin treatment group after streptozotocin implementation everyday at 18.00 for seven days. Only a single dose of streptozotocin was implemented to diabetic group. Control group had no intervention throughout the study. In the end of the experiment, blood was taken and rats were sacrificed. Before the sacrifice process rats’ fasting blood pressure was measured. Hexokinases, pyruvate kinase, glucose-6-phosphatase, fructose - 1,6-bisphosphatase, glucose -6 phosphate dehydrogenase levels were measured in the liver samples. Results: Between control and experimental groups of rats, there are statistically significant differences between control and experimental groups for all parameters. Melatonin protecting group levels of investigated parameters were more close to that of control groups’ values and results are statistically significant. Moreover, melatonin treatment group showed a protective effect. However it is not effective as melatonin protecting group. Conclusion: It can be suggested that melatonin shows protective effect on enzymes related to glucose metabolism in the liver tissue in a model of streptozotocin-induced experimental diabetes.
机译：目的：本实验研究旨在探讨褪黑激素对调节肝脏组织葡萄糖代谢的酶的保护作用。方法：在本实验研究中，使用了四个月大的雄性Wistar白化病大鼠。将大鼠分为4组，每组7只。将大鼠分为对照组，糖尿病组，褪黑激素保护组和褪黑激素治疗组。在链脲佐菌素每天7：00实施褪黑激素保护组之前（七天前）实施褪黑素治疗7天。另一方面，褪黑激素在链脲佐菌素每天18.00实施7天后施用于褪黑激素治疗组。糖尿病组仅使用单剂量的链脲佐菌素。对照组在整个研究过程中没有干预。实验结束时，采血并处死大鼠。在处死过程之前，先测量大鼠的空腹血压。在肝脏样品中测量了己糖激酶，丙酮酸激酶，葡萄糖-6-磷酸酶，果糖-1,6-双磷酸酶，葡萄糖-6-磷酸脱氢酶的水平。结果：在对照组和实验组之间，所有参数在对照组和实验组之间存在统计学上的显着差异。研究参数的褪黑激素保护组水平更接近于对照组的水平，结果具有统计学意义。此外，褪黑素治疗组显示出保护作用。然而，它作为褪黑激素保护基是无效的。结论：在链脲佐菌素诱发的实验性糖尿病模型中，褪黑激素可能对肝脏组织中与葡萄糖代谢相关的酶具有保护作用。

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