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The prevalence of incidental neuroendocrine tumours in the appendectomy materials: Ten-year s archive search

机译：阑尾切除术材料中偶发性神经内分泌肿瘤的患病率：十年档案搜索

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Objective: Aimed to investigate the incidence of neuroendocrine tumors (NET) in the appendectomy specimens of the patients who underwent appendectomy for various indications. Methods: 2252 cases, that were performed appendectomy at Harran University Faculty of Medicine and examined histopathologically in Pathology department between January 2004 and May 2014, were analyzed retrospectively. Results: In the study, it was reported NET in only 3 (0.13%) of these patients. All of the patients with NET were women and mean age ± SD was 58,33 ± 18.14 years. All of the patients had been operated for acute appendicitis and the tumor was detected incidentally during microscopic examination. The tumor was localized to the distal portion of the appendix in all cases, the tumor sizes were 1.4cm, 1cm, 0.7cm (mean: 1,03 ± 0,35), respectively. Although, muscular layer and periappendicular fatty tissue involvement was present in each case, cellular atypia was minimal. Mitotic activity was calculated as 1-2 in 10 high power field. Immunohistochemical staining was performed in all cases and tumor cells showed positive staining with pancytokeratin, synaptophysin and chromogranin in all. Ki-67 proliferative indices were found 1-2%. In all cases, the presence of acute appendicitis had been reported in the peritumoral appendix. Conclusion: On histopathological examination of the excised appendiceal materials, NET should be constantly kept in mind in differential diagnosis and should be evaluated by an appropriate sampling.
机译：目的：旨在研究因各种适应症而接受阑尾切除术的患者阑尾切除术标本中神经内分泌肿瘤（NET）的发生率。方法：回顾性分析2004年1月至2014年5月在哈兰大学医学院进行阑尾切除术并在病理科进行组织病理学检查的2252例病例。结果：在该研究中，仅3例（0.13％）报道了NET。所有NET患者均为女性，平均年龄±SD为58,33±18.14岁。所有患者均已接受急性阑尾炎手术，并且在显微镜检查中偶然发现了肿瘤。在所有情况下，肿瘤均位于阑尾的远端，肿瘤大小分别为1.4cm，1cm，0.7cm（平均：1.03±0.35）。尽管在每种情况下都存在肌肉层和阑尾周围脂肪组织受累，但细胞异型性很少。在10个高倍视野中有丝分裂活性被计算为1-2。在所有情况下均进行了免疫组织化学染色，并且肿瘤细胞在所有细胞中均显示出全细胞角蛋白，突触素和嗜铬粒蛋白的阳性染色。发现Ki-67增殖指数为1-2％。在所有情况下，在肿瘤周围的阑尾中都有急性阑尾炎的报道。结论：在对切除的阑尾材料进行组织病理学检查时，在鉴别诊断中应始终牢记NET，并应通过适当的采样进行评估。

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