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首页> 外文期刊>Journal of Clinical and Experimental Investigations >Evaluation of serum cortisol and dehydroepiandrosterone sulphate levels in parkinson patients with and without postural instability
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Evaluation of serum cortisol and dehydroepiandrosterone sulphate levels in parkinson patients with and without postural instability

机译：帕金森病患者在有姿势不稳和没有姿势不稳的情况下对血清皮质醇和硫酸脱氢表雄酮硫酸盐水平的评估

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Objective: Parkinson’s disease (PD) is the second most common neurodegenerative disease. During PD many disorders occur in the neuroendocrine mechanism along with autonomic dysfunction. The aim of this study was to evaluate the values of cortisol and dehydroepiandrosterone sulphate (DHEAS) in idiopathic PD patients with postural instability (PI) in the medium and advanced stages of the disease. Methods: Three groups were included in this study; patients with PI, patients without PI and control subjects. Each of the groups consisted of 30 patients. The fasting serum cortisol and DHEAS values of patients were obtained. Results: Serum cortisol levels were significantly higher in patients with PI in the advanced stage of PD, whereas DHEAS levels were significantly higher in patients without PI in the early stage. Conclusion: This situation was evaluated as the reflection of neuroendocrine response that occurred secondary to the progressive advancing neurodegeneration seen in PD patients. The data obtained may contribute to a better understanding of the pathophysiology of PD that in intermediate and advanced stages. In addition, our findings may help in establishing new treatment options for PD patients in the future.
机译：目的：帕金森氏病（PD）是第二常见的神经退行性疾病。在PD期间，神经内分泌机制会发生许多疾病，并伴有自主神经功能障碍。这项研究的目的是评估在疾病中期和晚期患有姿势不稳（PI）的特发性PD患者中皮质醇和硫酸脱氢表雄酮硫酸盐（DHEAS）的价值。方法：本研究分为三组。有PI的患者，无PI的患者和对照组。每个组由30名患者组成。获得患者的空腹血清皮质醇和DHEAS值。结果：PD晚期的PI患者的血清皮质醇水平显着升高，而早期无PI的患者的DHEAS水平显着升高。结论：这种情况被评估为反映了PD患者中继发于进行性神经退行性变继发的神经内分泌反应。获得的数据可能有助于更好地了解中晚期的PD的病理生理。此外，我们的发现可能有助于将来为PD患者建立新的治疗选择。

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