• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Experimental Investigations >Effect of erythropoietin use on mean platelet volume in children undergoing chronic dialysis
【24h】

Effect of erythropoietin use on mean platelet volume in children undergoing chronic dialysis

机译：促红细胞生成素的使用对慢性透析患儿平均血小板体积的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: In this study, it was aimed to determine the relationship between erythropoietin (EPO) use and mean platelet volume (MPV) in the children undergoing dialysis. Methods: MPV values before and after EPO use in 36 patients (16 hemodialysis - HD, 20 peritoneal dialysis - PD) were retrospectively evaluated. Patients were divided into two groups according to weekly EPO need as; given less than 150 U/kg defined as low EPO and more than 150 U/kg as high EPO groups. The age, weight, primary cause of chronic renal failure, dialysis methods and EPO dosages of patients were recorded. Blood samples were taken before and 4 weeks after EPO usage and MPV values were noted from complete blood counts. Results: While significant increase was seen in the MPV values after EPO in comparison to MPV values before EPO in the HD group (8.18±1.52 fL vs. 9.20±1.46 fL; p=0.046); near significant difference was found in the MPV levels after EPO (8.28±1.80 fL vs. 9.39±1.50 fL; p=0,051) in PD group. In HD patients when high dose of EPO was given, MPV levels were found to be significantly elevated (7.81 ± 1.04 vs 9.61 ± 1.05; p=0.06) after EPO. However, no difference was seen with the lowe dose EPO subgroup (8.64 ± 1.97 ve 8.67 ± 1.81; p>0,05). No effect of EPO dose was found on MPV values in PD patients (9.57 ± 1.58 ve 9.1 ± 1.42; p>0.05). Conclusion: It was observed that EPO influenced MPV values in children undergoing HD, while no effect of erythropoietin was found on MPV values of PD patients. Physicians should be careful while using high dose erythropoietin in children with high thrombosis risk.
机译：目的：本研究旨在确定接受透析的儿童中促红细胞生成素（EPO）的使用与平均血小板体积（MPV）之间的关系。方法：回顾性评估36例EPO使用前后的MPV值（16例血液透析-HD，20例腹膜透析-PD）。根据每周的EPO需要将患者分为两组。低于150 U / kg被定义为低EPO，高于150 U / kg被定义为高EPO组。记录患者的年龄，体重，慢性肾功能衰竭的主要原因，透析方法和EPO剂量。在使用EPO之前和之后4周采集血样，并从全血细胞计数中记录MPV值。结果：与HD组EPO之前的MPV值相比，EPO后的MPV值显着增加（8.18±1.52 fL对9.20±1.46 fL; p = 0.046）。 PD组的EPO后MPV水平几乎无显着差异（8.28±1.80 fL对9.39±1.50 fL; p = 0.051）。在接受高剂量EPO的HD患者中，发现EPO后MPV水平显着升高（7.81±1.04对9.61±1.05; p = 0.06）。但是，低剂量EPO亚组没有差异（8.64±1.97 ve 8.67±1.81; p> 0.05）。 EPD剂量对PD患者的MPV值无影响（9.57±1.58 ve 9.1±1.42; p> 0.05）。结论：观察到EPO影响HD患儿的MPV值，而未发现促红细胞生成素对PD患者MPV值的影响。在有高血栓形成风险的儿童中使用大剂量促红细胞生成素时，医生应格外小心。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号