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首页> 外文期刊>Journal of Clinical Sciences >Left ventricular mass, geometric patterns, and diastolic myocardial performance in children with chronic kidney disease
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Left ventricular mass, geometric patterns, and diastolic myocardial performance in children with chronic kidney disease

机译：慢性肾脏病患儿的左心室质量，几何形态和舒张期心肌表现

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Background: Excessive left ventricular mass (LVM) and diastolic dysfunction are associated with higher morbidity and mortality among patients with chronic kidney disease (CKD). Objective: The objective of the following study is to determine the prevalence of increased LVM index (LVMI), pattern of abnormal LV geometry, and diastolic dysfunction in Nigerian CKD children and to establish a relationship of these with estimated glomerular filtration rate (eGFR). Subjects and Methods: Cross-sectional comparative study of LV structure and diastolic function of 21 children with CKD age- and sex-matched and controls asymptomatic for cardiac disease. Results: The median LVMI was 62.19 (34.7) g/m2 in CKD patients compared with 52.89 (30.2) g/m2 in controls (P = 0.04). Excessive LVMI was present in 3 (14.3%) individuals compared with none (0%) of the controls P 2/min. Abnormal LV geometry was present in 19.05% of the CKD patients and none of the controls (P = 0.04). CKD stages differed significantly with respect to the presence of abnormality with LV geometry (P = 0.04). LV diastolic dysfunction was present in 4 (19.1%) individuals (2 each had impaired relaxation and restrictive patterns) compared with 1 (4.8%) control (restrictive pattern)-P 0.001. Children with CKD who had abnormal LV geometry had 48 times increase in the odds of having LV diastolic dysfunction when compared with those having normal LV geometry (confidence interval = 2.31–997.18, P = 0.012). Conclusion: Excessive LVM, LV hypertrophy and diastolic dysfunction are significantly more common in children with CKD compared with controls.
机译：背景：慢性肾脏病（CKD）患者的左心室质量过多（LVM）和舒张功能障碍与较高的发病率和死亡率相关。目的：以下研究的目的是确定尼日利亚CKD儿童LVM指数（LVMI）升高，左心室几何形态异常和舒张功能障碍的患病率，并确定这些因素与估​​计的肾小球滤过率（eGFR）之间的关系。研究对象和方法：对21例年龄和性别相符且无症状的CKD患儿的LV结构和舒张功能进行横断面比较研究。结果：CKD患者的LVMI中位数为62.19（34.7）g / m2，而对照组为52.89（30.2）g / m2（P = 0.04）。 LVMI过多存在于3（14.3％）个个体中，而对照组的PMI / min则为零（0％）。 19.05％的CKD患者存在左室几何形态异常，而对照组均无（P = 0.04）。相对于左心室几何形态的异常，CKD分期显着不同（P = 0.04）。左室舒张功能障碍存在于4（19.1％）个个体中（每个人有2个放松和限制性模式受损），而对照组（限制性模式）为1个（4.8％）-P 0.001。 LV几何异常的CKD患儿与正常LV几何患儿相比，LV舒张功能障碍的几率增加48倍（置信区间= 2.31–997.18，P = 0.012）。结论：与对照组相比，CKD患儿的LVM过多，LV肥大和舒张功能障碍更为常见。

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