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首页> 外文期刊>Journal of Clinical Sciences >Sezary syndrome in a 65-year-old schizophrenic patient
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Sezary syndrome in a 65-year-old schizophrenic patient

机译：一名65岁精神分裂症患者的Sezary综合征

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Sezary syndrome (SS) is the leukemic variant of cutaneous T-cell lymphoma characterized by a triad of erythroderma, peripheral lymphadenopathy, and the presence of circulating atypical lymphoid cells (Sezary cells) in the blood. We present a 65-year-old female with a recent-onset schizophrenia, presenting with a 3-year history of recurrent generalized pruritus, erythroderma, and a 2-month history of recent-onset, mushroom-like skin tumors. Examination revealed generalized erythroderma affecting more than 80% of total body surface area and significant peripheral lymphadenopathy. Peripheral blood buffy coat examination showed Sezary cells which constituted more than 18% of total circulating lymphoid cells, and histology report of the wedge biopsy of skin tumor confirmed mycosis fungoides. The patient was commenced on cytotoxic chemotherapy with some improvement in symptoms. However, she relapsed 2 months later, with development of new fungating tumors and died from overwhelming sepsis. We report this case to highlight the occurrence of two comorbidities together, each of which may negatively worsen the progression of the other, and to report a case of SS as one of the rare causes of generalized exfoliative dermatitis. Thus, there is a need for early skin biopsy and histology in any elderly patient presenting with recurrent generalized pruritus and erythroderma.
机译：Sezary综合征（SS）是皮肤T细胞淋巴瘤的白血病变体，其特征是三联症为红皮病，外周淋巴结病和血液中存在循环性非典型淋巴样细胞（Sezary细胞）。我们介绍了一位65岁的女性，患有近期发作的精神分裂症，具有3年复发的全身性瘙痒症，红皮病史，以及2个月的近期发作，蘑菇样皮肤肿瘤史。检查发现全身性红皮病影响全身总表面积的80％以上，并伴有明显的外周淋巴结肿大。外周血白细胞层检查显示，Sezary细胞占总循环淋巴样细胞的18％以上，皮肤肿瘤楔形活检的组织学报告证实了真菌病真菌。患者开始接受细胞毒性化学疗法，症状有所改善。但是，她在2个月后复发，出现了新的真菌性肿瘤，死于败血症。我们报告此病例以突出显示两种合并症的发生，每种合并症都可能不利地恶化另一种合并症，并报告一例SS是广泛性剥脱性皮炎的罕见原因之一。因此，需要对任何患有复发性全身瘙痒和红皮病的老年患者进行早期皮肤活检和组织学检查。

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