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首页> 外文期刊>Journal of Clinical Sciences >Medication adherence and influencing factors in patients with type 2 diabetes attending a tertiary hospital in South-West Nigeria
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Medication adherence and influencing factors in patients with type 2 diabetes attending a tertiary hospital in South-West Nigeria

机译：尼日利亚西南部三级医院就诊的2型糖尿病患者的药物依从性及其影响因素

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Background and Objectives: Adherence to antidiabetic medications represents a huge hurdle that needs to be overcome for patients to gain maximum clinical benefits from their therapies. Several factors have been associated with patient adherence. This study assessed adherence to antidiabetic medications and evaluated the influence of pill burden on adherence. Materials and Methods: This is a cross-sectional study of 418 consenting patients with established type 2 diabetes attending the endocrinology Outpatient Clinic of a Tertiary Hospital. Patients were approached consecutively and surveyed using a questionnaire comprising information on demographics, medication adherence, and factors affecting adherence. Data on medication regimen and comorbidities were extracted from participants' case records. The study lasted for 15 months. Data were analyzed and summarized using descriptive and inferential statistics. Results: Nearly 27.5% of the participants were adjudged nonadherent to antidiabetic medications. The average number of antidiabetics was 1.56 ± 0.617. Of the number of participants that are adherent, nearly 33% and 35% of them were on one and two antidiabetic medications, respectively. However, been on three or more medications is associated with poorer adherence. Participants on metformin had better adherence compared to those on insulin alone or insulin plus oral antidiabetics. Short duration of diabetes (P = 0.048), older age (P = 0.024), and high educational level (P = 0.002) are associated with better adherence. Conclusion: A substantial number of patients were non-adherent to their antidiabetic medications. Been prescribed 3 or more antidiabetic medications was associated with poor adherence. The association between adherence to medication and glycemic control is not significant. High Pill-burden, young age, low educational level are potential targets for interventions.
机译：背景与目的：坚持抗糖尿病药物治疗是一个巨大的障碍，患者要想从治疗中获得最大的临床收益，就必须克服这一障碍。几个因素与患者的依从性有关。这项研究评估了抗糖尿病药物的依从性，并评估了药丸负荷对依从性的影响。材料和方法：这是一项横断面研究，涉及418位在三级医院内分泌科门诊就诊的2型糖尿病患者。连续接触患者并使用问卷调查，问卷包括人口统计学，药物依从性和影响依从性的信息。药物治疗方案和合并症的数据是从参与者的病历中提取的。该研究持续了15个月。使用描述性和推断性统计数据对数据进行分析和汇总。结果：将近27.5％的参与者被判定为不遵守抗糖尿病药物。抗糖尿病药的平均数为1.56±0.617。在依从性参与者中，分别有近33％和35％的人服用一种和两种抗糖尿病药物。但是，服用三种或三种以上药物与依从性差有关。与单独使用胰岛素或胰岛素加口服降糖药的参与者相比，二甲双胍的参与者具有更好的依从性。糖尿病持续时间短（P = 0.048），年龄大（P = 0.024）和高学历（P = 0.002）与更好的依从性相关。结论：大量患者未坚持服用抗糖尿病药物。被处方3种或更多抗糖尿病药物与依从性差有关。对药物的依从性和血糖控制之间的关联并不显着。高药丸负担，低年龄，低文化程度是干预的潜在目标。

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