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首页> 外文期刊>Journal of Clinical Sciences >Sociodemographic correlates and management of breast cancer in Radiotherapy Department, Lagos University Teaching Hospital: A 10-year review
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Sociodemographic correlates and management of breast cancer in Radiotherapy Department, Lagos University Teaching Hospital: A 10-year review

机译：拉各斯大学教学医院放疗科乳腺癌的社会人口统计学相关性和处理：十年回顾

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Background: Worldwide, breast cancer is the most frequently diagnosed life-threatening malignant disease in women. Aim: The aim of the study was to determine the sociodemographic correlates and management of breast cancer in a tertiary hospital. Patients and Methods: Case notes of histologically confirmed breast cancer patients were retrieved, and data extracted were analyzed using the Statistical Package for the Social Sciences version 20 (SPSS Incorporation, Chicago, Illinois State, United States of America). Results: A total of 1141 cases were analyzed, of which 1132 (99.2%) were female and 9 (0.8%) were male, with a ratio of 1:126. The range was between 9 and 20 years. The mean age was 46.8 ± 12.2 years, whereas most of the cases were between 50 and 59 years (23.0%). The mean age at menarche was 14.7 ± 2.2 years, whereas less than two-third of the patients were between 13 and 16 years (63.4%). The mean age at first pregnancy was 24.3 ± 4.7 years, whereas majority of them were between 20 and 29 years (71.4%). The mean age at menopause was 49.0 ± 5.7 years, whereas more than a third of the patients were between 45 and 49 years (37.5%). The median number of children ever born was 4 (interquartile range [IQR]: 3–5). Majority of the patients are married (84.1%). The median duration of breastfeeding of the patients was 12 (IQR: 12–18) months. The mean body mass index was 28.6 ± 6.5, whereas about a third of them are obese (34.7%). Majority of the patients have unskilled occupation (51.1%). The test of association between sociodemographic characteristics and histology status revealed a significant association between age of patients (P = 0.013**), marital status (P = 0.027**), age at menarche (P = 0.009**), and number of children (P = 0.034**). The test of association between sociodemographic characteristics and stage of disease revealed a significant association between age at menarche (P = 0.018**), age at menopause (P = 0.041**), age at pregnancy (P = 0.036**), and body mass index (P = 0.028**). A total of 213 (30.9%) cases had combined treatment, 289 (59.4%) had a mastectomy, and 294 (71.6%) had radiotherapy. The treatment outcome revealed that 549 (48.1%) were lost to follow-up, 447 (39.2%) were dead, and 145 (12.7%) were alive after 2 years posttreatment. Conclusion: Sociodemographic characteristics such as age of patients, age at menarche, and marital status had a significant association with histology, whereas age at menarche, age at menopause, age at pregnancy, and body index mass had a significant association with stage of disease, therefore influencing health outcomes for breast cancer.
机译：背景：在全球范围内，乳腺癌是女性中最常被诊断为威胁生命的恶性疾病。目的：该研究的目的是确定一家三级医院的社会人口统计学相关性和乳腺癌的治疗方法。患者和方法：检索经组织学确认的乳腺癌患者的病例记录，并使用《社会科学统计软件包》第20版（SPSS公司，美国伊利诺伊州芝加哥市）对提取的数据进行分析。结果：共分析1141例，其中女性1132例（99.2％），男性9例（0.8％），比例为1：126。范围是9到20年。平均年龄为46.8±12.2岁，而大多数病例在50至59岁之间（23.0％）。初潮的平均年龄为14.7±2.2岁，而不到三分之二的患者在13至16岁之间（63.4％）。初次怀孕的平均年龄为24.3±4.7岁，而大多数人在20至29岁之间（71.4％）。绝经的平均年龄为49.0±5.7岁，而超过三分之一的患者在45至49岁之间（37.5％）。出生的孩子的中位数为4（四分位间距[IQR]：3-5）。多数患者已婚（84.1％）。患者母乳喂养的中位时间为12（IQR：12-18）个月。平均体重指数为28.6±6.5，其中约三分之一是肥胖的（34.7％）。大部分患者是非技术职业（51.1％）。社会人口统计学特征与组织学状态之间的关联测试显示，患者年龄（P = 0.013 **），婚姻状况（P = 0.027 **），初潮年龄（P = 0.009 **）和患病人数之间存在显着相关性。儿童（P = 0.034 **）。社会人口统计学特征与疾病阶段之间的关联测试显示，初潮年龄（P = 0.018 **），绝经年龄（P = 0.041 **），妊娠年龄（P = 0.036 **）和体重指数（P = 0.028 **）。共有213例（30.9％）接受了联合治疗，289例（59.4％）接受了乳房切除术，294例（71.6％）接受了放疗。治疗结果显示，在随访2年后，有549例（48.1％）失访，447例（39.2％）死亡，145例（12.7％）仍然活着。结论：患者年龄，初潮年龄和婚姻状况等社会人口统计学特征与组织学密切相关，而初潮年龄，绝经年龄，怀孕年龄和身体质量指数与疾病阶段密切相关，因此影响乳腺癌的健康结果。

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