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首页> 外文期刊>Journal of clinical biochemistry and nutrition. >Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice
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Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice

机译：喝氢水改善衰老加速小鼠的认知障碍

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Hydrogen has been reported to have neuron protective effects due to its antioxidant properties, but the effects of hydrogen on cognitive impairment due to senescence-related brain alterations and the underlying mechanisms have not been characterized. In this study, we investigated the efficacies of drinking hydrogen water for prevention of spatial memory decline and age-related brain alterations using senescence-accelerated prone mouse 8 (SAMP8), which exhibits early aging syndromes including declining learning ability and memory. However, treatment with hydrogen water for 30 days prevented age-related declines in cognitive ability seen in SAMP8 as assessed by a water maze test and was associated with increased brain serotonin levels and elevated serum antioxidant activity. In addition, drinking hydrogen water for 18 weeks inhibited neurodegeneration in hippocampus, while marked loss of neurons was noted in control, aged brains of mice receiving regular water. On the basis of our results, hydrogen water merits further investigation for possible therapeutic/preventative use for age-related cognitive disorders.
机译：氢由于其抗氧化特性而被报道具有神经元保护作用，但是氢对衰老相关的脑部改变和其潜在机制的认知障碍的作用尚未被表征。在这项研究中，我们研究了使用衰老加速俯卧鼠8（SAMP8）来喝氢水预防空间记忆衰退和与年龄有关的大脑变化的功效，该老鼠表现出包括学习能力和记忆力下降在内的早期衰老综合征。然而，通过水迷宫测试评估，用氢气水治疗30天可防止SAMP8中所见的与年龄相关的认知能力下降，并且与脑5-羟色胺水平升高和血清抗氧化活性升高有关。此外，喝氢水18周可抑制海马神经退行性变，而在接受常规饮水的老鼠的对照组，老龄脑中，神经元明显减少。根据我们的研究结果，对于与年龄有关的认知障碍可能的治疗/预防用途，氢水值得进一步研究。

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