...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of clinical laboratory analysis. >Clonal dominance of a donor‐derived del(20q) clone after allogeneic hematopoietic stem cell transplantation in an acute myeloid leukemia patient with del(20q)
【24h】

Clonal dominance of a donor‐derived del(20q) clone after allogeneic hematopoietic stem cell transplantation in an acute myeloid leukemia patient with del(20q)

机译：急性髓样白血病del（20q）患者异体造血干细胞移植后，供体来源的del（20q）克隆的克隆优势

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Del(20q) is the most frequently detected large structural genetic mosaicism alteration in the healthy aging population, occurring in approximately 0.1% of older persons. Age‐related clonal hematopoiesis of copy number variations (CNVs) is linked to an increased risk of hematologic malignancies, but the clinical impact of hematopoietic stem cells (HSCs) harboring such CNVs, such as del(20q), is not clearly understood. Here, we report an acute myeloid leukemia (AML) patient with known del(20q) who acquired donor‐derived del(20q) after allogeneic hematopoietic stem cell transplantation (HSCT). The HSCs with del(20q) engrafted and expanded over time, but the patient did not clinically progress to myeloid neoplasm. Although donor‐derived del(20q) from a healthy donor has been reported previously, our case is the first to review the clonal dynamics of a del(20q) clone and its post‐transplantation impact. Since recurrent hematology neoplasm‐associated CNVs, including del(20q), may not be rare among aged HSCT donors, identifying the origin of such a CNV is necessary for clinical decisions when clonal abnormality appears after HSCT, even in recipients who previously had the same abnormality.
机译：Del（20q）是在健康的老龄人口中最常检测到的大型结构遗传镶嵌改变，约占0.1％的老年人。年龄相关的拷贝数变异（CNV）克隆性造血与血液系统恶性肿瘤风险增加相关，但是尚不清楚带有此类CNV的造血干细胞（HSC）的临床影响，例如del（20q）。在此，我们报道了一名急性dele（20q）的急性髓细胞白血病（AML）患者，该患者在异基因造血干细胞移植（HSCT）后获得了供体来源的del（20q）。随着时间的推移，带有del（20q）的HSC会移入并扩展，但该患者在临床上并未进展为骨髓瘤。尽管先前已经报道了来自健康供体的供体来源的del（20q），但我们的案例是第一个综述del（20q）克隆的克隆动态及其移植后影响的案例。由于复发性血液学肿瘤相关的CNV包括del（20q）在老年HSCT供体中可能并不罕见，因此，当HSCT后出现克隆异常时，即使在先前有相同经验的接受者中，也要确定这种CNV的来源对于临床决策是必要的紊乱ETC。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号