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首页> 外文期刊>Journal of Cosmetics, Dermatological Sciences and Applications >Semi-Quantitative Histological Analysis of the Effect of Intense Pulsed Light (IPL) and Carbon Dioxide (CO2) Intradermic Injection on Fibroblast and Collagen Proliferation in the Skin of Wistar Rats
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Semi-Quantitative Histological Analysis of the Effect of Intense Pulsed Light (IPL) and Carbon Dioxide (CO2) Intradermic Injection on Fibroblast and Collagen Proliferation in the Skin of Wistar Rats

机译：半定量组织学分析强脉冲光（IPL）和二氧化碳（CO2）皮内注射对Wistar大鼠皮肤成纤维细胞和胶原增殖的影响

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Background: In recent years, so-called “non-ablative rejuvenation” has been carried out with the use of lasers or intense pulsed light (IPL) to stimulate collagen production by dermal fibroblasts. Intradermal infusion of CO2 stimulates fibroblasts and the synthesis of collagen and elastin, contributing to the retraction of the skin and tissue rejuvenation. Objectives: To evaluate the effects of IPL and the intradermal infusion of CO2 on fibroblast proliferation and collagen in the skin of female rats. Methods: Sixteen adult female Wistar rats were divided into two groups of eight animals. Group 1 underwent IPL and group 2 underwent intradermal CO2 infusion. There was a total of 8 weeks of treatment. We conducted a punch in each animal before any procedure (T0), another punch in the middle of treatment at 4 weeks post-procedure (T1) and a punch at the end of treatment at 8 weeks post-procedure (T2). The cells involved in inflammation, fibrosis and vascularization of the injured tissue by histopathology were analyzed. Results: There was statistically significant fibroblast proliferation and collagen proliferation noted when analyzing all 16 animals together and also when considering the two study groups separately. In both groups, the greatest proliferation of fibroblasts coincided with periods of increased collagen production. Conclusion: Both IPL and intradermal CO2 infusion stimulated fibroblast and collagen proliferation in the skin of the rats studied.
机译：背景：近年来，通过使用激光或强脉冲光（IPL）刺激真皮成纤维细胞产生胶原蛋白，进行了所谓的“非消融嫩肤”。皮内注入二氧化碳会刺激成纤维细胞以及胶原蛋白和弹性蛋白的合成，从而有助于皮肤的收缩和组织的年轻化。目的：评价IPL和皮内注入CO2对雌性大鼠皮肤成纤维细胞增殖和胶原蛋白的影响。方法：将十六只成年雌性Wistar大鼠分成两组，每组八只动物。第1组进行IPL，第2组进行皮内CO2输注。总共进行了8周的治疗。我们对每只动物在进行任何手术之前都进行了拳打（T0），在治疗中途在操作后4周（T1）进行了另一拳，并且在治疗结束时在术后8周（T2）进行了处理。通过组织病理学分析了与受伤组织的炎症，纤维化和血管化有关的细胞。结果：在一起分析所有16只动物时，以及分别考虑两个研究组时，都注意到统计学上显着的成纤维细胞增殖和胶原增殖。在两组中，成纤维细胞的最大增殖与胶原蛋白产生增加的时期相吻合。结论：IPL和皮内注入CO2均可刺激大鼠皮肤中的成纤维细胞和胶原蛋白增殖。

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