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首页> 外文期刊>Journal of Endocrinology and Metabolism >The Effects of Supraphysiologic Doses of Vitamin D3 in Conjunction With Teriparatide on Bone Mineral Density in Two Postmenopausal Females With Severe Osteoporosis
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The Effects of Supraphysiologic Doses of Vitamin D3 in Conjunction With Teriparatide on Bone Mineral Density in Two Postmenopausal Females With Severe Osteoporosis

机译：超生理学剂量的维生素D3与特立帕肽联合治疗对两名绝经后骨质疏松症女性的骨矿物质密度的影响

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Teriparatide was approved by the FDA in 2002 for the treatment of osteoporosis in postmenopausal women who are at high risk for fractures. Previous studies involving the use of teriparatide in conjunction with vitamin D and calcium supplementation have suggested that sufficient vitamin D levels may not be a requirement to achieve an effective response to teriparatide. We present a case of two postmenopausal females with severe osteoporosis who were treated with teriparatide along with calcium and supraphysiologic doses of vitamin D, as illustrated by an increase from their baseline serum 25-hydroxyvitamin D concentrations. Both patients experienced an increase in bone mineral density that was significantly higher than what has been seen in prior studies of teriparatide administration in conjunction with physiologic doses of vitamin D. These findings suggest that administering supraphysiologic doses of vitamin D may in fact potentiate the effects of teriparatide in postmenopausal females with osteoporosis, resulting in larger increases in bone mineral density than would otherwise be expected.doi:10.4021/jem104w
机译：Teriparatide在2002年获得FDA的批准，用于治疗高骨折风险的绝经后妇女的骨质疏松症。先前涉及使用特立帕肽联合维生素D和钙补充剂的研究表明，对于实现对特立帕肽的有效反应，可能不需要足够的维生素D水平。我们介绍了两名患有绝经后严重骨质疏松症的女性，他们接受了特立帕肽，钙和超生理剂量的维生素D的治疗，从基线血清25-羟基维生素D的浓度增加可以看出。两名患者的骨矿物质密度增加均显着高于先前服用特立帕肽与生理剂量维生素D的研究结果。这些发现表明，超生理剂量的维生素D的给药实际上可以增强维生素D的作用。绝经后患有骨质疏松症的女性使用特立帕肽，导致骨骼矿物质密度的增加幅度超过了预期。doi：10.4021 / jem104w

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