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首页> 外文期刊>Journal of Drug Delivery and Therapeutics >Antioxidant properties and subchronic toxicity of the standardized extract of LAMIC, a phytomedicine prototype based on aqueous extracts from trunk bark of Lannea microcarpa Engl and K. Krause
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Antioxidant properties and subchronic toxicity of the standardized extract of LAMIC, a phytomedicine prototype based on aqueous extracts from trunk bark of Lannea microcarpa Engl and K. Krause

机译：LAMIC标准化提取物的抗氧化性能和亚慢性毒性，LAMIC是一种植物提取物原型，该植物提取物是基于Lannea microcarpa Engl和K. Krause树干的水提取物制成的。

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Aims: This study investigated the antioxidant activity and the 90 days subchronic toxicity of the standardized LAMIC phytomedicine prototype based on aqueous extracts from Lannea microcarpa trunk bark. Methods: Three spectrophotometric methods were used to evaluated the antioxidant activity of LAMIC which were 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical, 2,2’-azinobis(3-ethylbenzolin-6-sulphonate) (ABTS) radical scavenging assays and ferric reducing antioxidant power (FRAP) assays. For the standardized LAMIC subchronic toxicity study, male and female Wistar rats were used by daily oral administration at doses of 500, 1000 and 1500 mg/kg bw consecutively for 90 days. Results: The LAMIC extract exhibit better inhibitory activity against DPPH radical than ABTS radical with respective ICsub50 /subvalues of 45.38±3.21 μg/mL and 66.45±18.76 μg/mL, while FRAP assay exhibit antioxidant activity of 211.34±15.92 mmol EAA/g. Subchronic oral administration of LAMIC was well-tolerated at all tested doses. No behavioral and physiological changes and mortality were observed. The LAMIC extract did not present any impact on general hematological parameters and biochemical parameters. Moreover, no significant changes were raised in organ and body weight of treated groups compared to the Control group. Conclusion: These results support that LAMIC prototype was a valuable source of natural antioxidants and no toxicity was associated to its long terms oral consumption in rats indicating a potential application as a cardiovascular protective formulation.
机译：目的：本研究调查了基于来自小nea皮树皮的水提取物的标准化LAMIC植物药原型的抗氧化活性和90天的亚慢性毒性。方法：采用3种分光光度法评估了LAMIC的抗氧化活性，分别为2,2-二苯基-1-吡啶并肼基（DPPH），2,2'-叠氮基双（3-乙基苯并林-6-磺酸根）（ABTS）。清除测定法和铁还原抗氧化能力（FRAP）测定法。对于标准化的LAMIC亚慢性毒性研究，雄性和雌性Wistar大鼠连续90天每天口服，剂量分别为500、1000和1500 mg / kg bw。结果：LAMIC提取物对DPPH自由基的抑制作用优于ABTS自由基，其IC 50 值分别为45.38±3.21μg/ mL和66.45±18.76μg/ mL，而FRAP测定的抗氧化活性为211.34 ±15.92 mmol EAA /克。在所有测试剂量下，亚慢性口服LAMIC耐受性良好。没有观察到行为和生理变化以及死亡率。 LAMIC提取物对一般血液学参数和生化参数没有任何影响。此外，与对照组相比，治疗组的器官和体重没有显着变化。结论：这些结果支持LAMIC原型是天然抗氧化剂的宝贵来源，并且与大鼠长期口服食用没有毒性相关，表明其潜在用途可作为心血管保护制剂。

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