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首页> 外文期刊>Journal of Drug Delivery and Therapeutics >Fabrication and Characterization of Anticancer Drug Loaded Double Walled Microspheres
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Fabrication and Characterization of Anticancer Drug Loaded Double Walled Microspheres

机译：载有抗癌药的双壁微球的制备与表征

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In the present work, double walled microspheres of Tamoxifen (antiestrogenic drug) using?Sodium alginate, Hydroxy propyl methyl cellulose (HPMC) K100,Guar gum, Xanthun gum were formulated to deliver Tamoxifen (TMX) through oral?route to treat breast cancer patients. Details regarding the preparation and evaluation of the formulations have been discussed in results. From the study following conclusions could be drawn. The results of this investigation indicate that Ion gelation method can be successfully employed to fabricate TMX microspheres. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers?and?copolymer?used. Microspheres containing sodium alginate along with HPMC in 1:1 ratio had?a least size range?of 610μm. Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size. The invitro drug release decreased with increase in the polymer and copolymer concentration. Among all formulations F7 shows Maximum drug release in 12 th hr when compared with other formulations. Analysis of drug release mechanism showed that the drug release from the formulations?followed?the Non fickian diffusion mechanism and follows zero order kinectics. Based?on?the?results?of?evaluation?tests?formulation coded F7 was concluded as best?formulation.
机译：在目前的工作中，使用海藻酸钠，羟丙基甲基纤维素（HPMC）K100，瓜尔胶，黄原胶的三苯氧胺（抗雌激素药物）双壁微球被配制为通过口服途径递送三苯氧胺（TMX）以治疗乳腺癌患者。 。结果中讨论了有关制剂制备和评估的详细信息。从研究中可以得出以下结论。这项研究的结果表明，离子凝胶法可以成功地用于制备TMX微球。物理混合物的FT-IR光谱表明该药物与所用的聚合物和共聚物相容。含有海藻酸钠和HPMC的比例为1：1的微球的最小尺寸范围为610μm。聚合物浓度的增加导致产率％，药物截留效率％，粒度的增加。体外药物释放随着聚合物和共聚物浓度的增加而降低。在所有配方中，与其他配方相比，F7在12小时内显示出最大的药物释放。对药物释放机理的分析表明，从制剂中释放出来的药物遵循非菲尼克斯扩散机理，并且遵循零阶运动学。根据评估测试结果，以F7编码的公式被认为是最佳公式。

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