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首页> 外文期刊>Journal of Applied Medical Sciences >Evaluation of albumin/globulin ratio as a diagnostic marker for relapsing ocular Beh?et’s disease
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Evaluation of albumin/globulin ratio as a diagnostic marker for relapsing ocular Beh?et’s disease

机译：评估白蛋白/球蛋白比作为复发性贝氏病的诊断指标

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Background: The aim of this study was to evaluate thealbumin/globulin (A/G) ratio as a diagnostic marker for relapsing ocular Beh?et’sdisease. Methods: This study was conducted using retrospective design.Patients of ocular Beh?et’s disease under infliximab infusion therapy wereregistered. The parameters for remission, i.e., total protein, albumin, serumprotein fraction, serum amyloid A (SAA), C reactive protein (CRP), erythrocytesedimentation rate (ESR), were monitored. The inflammatory proteins; α1-antitripsine, α1 acid glycoprotein, retinol binding protein,haptoglobin, ceruloplasmin, and α2 macroglobulin were measured during the pre- andpost- relapse phase in three patients. Results: Fourteen occurrences ofrelapse among 10 patients were confirmed during the study period. The A/G ratiodecreased to 0.10 ± 0.11 (mean ± SD), the increase in the mean percentage of α1 and α2 globulin fractions was statistically significant,and analysis of three patient samples showed an increase in α1 acid glycoprotein (p = 0.04) and a decrease inretinol binding protein (p = 0.04). Comparison of the A/G ratio with othermarkers, ESR, SAA, and CRP, between the pre- and post- relapse phase showedthat all four factors changed significantly.Conclusions: The A/G ratio appears to be a useful marker for relapsingocular Beh?et’s disease.
机译：背景：这项研究的目的是评估白蛋白/球蛋白（A / G）比作为复发性眼Beh？et病的诊断指标。方法：本研究采用回顾性设计进行。登记了英夫利昔单抗输注治疗的眼白塞氏病患者。监测缓解的参数，即总蛋白，白蛋白，血清蛋白组分，血清淀粉样蛋白A（SAA），C反应蛋白（CRP），红细胞沉降率（ESR）。炎性蛋白质;在三位患者的复发前后，分别测量了α1-抗tripsine，α1酸性糖蛋白，视黄醇结合蛋白，触珠蛋白，铜蓝蛋白和α2巨球蛋白。结果：在研究期间，确认10例患者中有14例复发。 A / G比降低至0.10±0.11（平均值±SD），α1和α2球蛋白分数的平均百分比增加具有统计学显着性，对三名患者样品的分析显示α1酸性糖蛋白增加（p = 0.04）和视黄醇结合蛋白减少（p = 0.04）。比较复发前和复发后阶段的A / G比率与其他标志物，ESR，SAA和CRP，发现所有四个因素均发生了显着变化。结论：A / G比率似乎是复发性Beh的有用标志物？等疾病。

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