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首页> 外文期刊>Journal of diabetes investigation. >Efficacy of metformin on postprandial plasma triglyceride concentration by administration timing in patients with type?2 diabetes mellitus: A randomized cross‐over pilot study
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Efficacy of metformin on postprandial plasma triglyceride concentration by administration timing in patients with type?2 diabetes mellitus: A randomized cross‐over pilot study

机译：二甲双胍对2型糖尿病患者餐后血浆甘油三酯浓度的影响（按给药时间）：一项随机交叉试验研究

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Aims/Introduction Preprandial metformin administration significantly reduces postprandial plasma triglyceride levels in animal studies by reducing intestinal absorption through delayed gastric emptying. However, this effect has not been shown in a clinical study. Therefore, we planned to investigate the efficacy of preprandial metformin administration on postprandial hypertriglyceridemia and the related gastrointestinal effects in patients with type?2 diabetes mellitus. Materials and Methods A total of 11 patients taking single‐dose metformin at 500–1,000?mg, with non‐fasting plasma triglyceride levels of 150–1,000?mg/dL, were recruited at a single university hospital. The difference between preprandial and postprandial metformin administration on postprandial hypertriglyceridemia was examined by a meal test. The gastrointestinal effects of metformin, including stomach heaviness, heartburn and satiety, were also assessed using a visual analog scale. Results The mean bodyweight of patients was 80.6?kg (body mass index 27.9?kg/msup2/sup), and the mean non‐fasting plasma triglyceride level was 275.9?±?57.0?mg/dL. The area under the curve of triglyceride during the meal test was significantly lower in the preprandial protocol than in the postprandial protocol ( P ?0.05). Compared with postprandial administration, preprandial administration of metformin increased satiety ( P =?0.036) without stomach heaviness or heartburn. Conclusions Preprandial metformin administration significantly reduced plasma triglyceride level during meal testing without marked exacerbation of gastrointestinal adverse effects. The present results suggest that a simple change in the timing of metformin administration represents a novel approach for enhancing triglyceride‐lowering strategies in patients with type?2 diabetes mellitus and postprandial hypertriglyceridemia.
机译：目的/简介在动物研究中，餐前服用二甲双胍可通过减少胃排空来减少肠道吸收，从而显着降低餐后血浆甘油三酯水平。但是，这种作用尚未在临床研究中显示。因此，我们计划研究餐前二甲双胍对2型糖尿病患者餐后高甘油三脂血症的疗效以及相关的胃肠道影响。资料与方法在一家大学医院中，共招募了11名服用500-1,000？mg单剂量二甲双胍且非禁食血浆甘油三酯水平为150-1,000？mg / dL的患者。通过进餐测试检查餐前和餐后二甲双胍对餐后高甘油三酯血症的差异。还使用视觉模拟量表评估了二甲双胍对胃肠的影响，包括胃沉重，胃灼热和饱腹感。结果患者的平均体重为80.6？kg（体重指数为27.9？kg / m 2 ），平均非禁食血浆甘油三酯水平为275.9？±？57.0？mg / dL。进餐试验中的甘油三酸酯曲线下面积显着低于餐前方案（P <？0.05）。与餐后给药相比，餐前给药二甲双胍可增加饱腹感（P =？0.036），而不会引起胃部不适或胃灼热。结论餐前二甲双胍可显着降低餐食期间血浆甘油三酯水平，而不会明显加剧胃肠道不良反应。目前的结果表明，二甲双胍给药时间的简单改变代表了一种新的方法，可增强2型糖尿病和餐后高甘油三酯血症患者的降低甘油三酯的策略。

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