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首页> 外文期刊>Dementia & Neuropsychologia >Associa??o entre lúpus eritematoso sistêmico e demência: um metanálise
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Associa??o entre lúpus eritematoso sistêmico e demência: um metanálise

机译：系统性红斑狼疮与痴呆之间的关联：一项荟萃分析

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Objective: To quantitatively evaluate the relationship of SLE and antiphospholipid antibodies (aPL) with cognitive dysfunction and dementia. Methods: All relevant literature was retrieved from Pubmed, Scopus, and PsycINFO databases. The meta-analysis was performed using effect estimates and 95% confidence intervals (CIs) to calculate pooled risk estimates. The heterogeneity among studies was also examined. Results: The meta-analysis included 11 original studies involving a total of 81,668 patients with dementia and 407 patients with cognitive dysfunction. There were significant associations on fixed-effect models between SLE and dementia (3 studies; RR=1.50; 95% CI=1.37-1.64), SLE and cognitive dysfunction (4 studies; OR=2.97; 95% CI=1.72-5.15), and aPL and cognitive dysfunction (5 studies, OR=1.97; 95% CI=1.55-2.52). We also combined cognitive dysfunction and dementia outcomes as they both represented cognitive impairment. There were significant associations between aPL and cognitive impairment (6 studies; OR=2.03; 95% CI=1.62-2.55), and SLE and cognitive impairment (7 studies; OR=1.83; 95% CI=1.42-2.35). Moderate heterogeneity (I 2 =45.7%) was found in the association between SLE and cognitive impairment, low heterogeneity (I 2 =21.8%) in the association between SLE and dementia, and near zero heterogeneity for the other three main analyses. Conclusion: Both SLE and aPL are associated with cognitive impairment.
机译：目的：定量评估SLE和抗磷脂抗体（aPL）与认知功能障碍和痴呆的关系。方法：所有相关文献均来自Pubmed，Scopus和PsycINFO数据库。使用效果评估和95％置信区间（CI）进行荟萃分析，以计算汇总风险评估。还检查了研究之间的异质性。结果：荟萃分析包括11项原始研究，涉及81,668例痴呆症患者和407例认知功能障碍患者。 SLE和痴呆之间的固定效应模型存在显着相关性（3个研究; RR = 1.50; 95％CI = 1.37-1.64），SLE和认知功能障碍（4个研究; OR = 2.97; 95％CI = 1.72-5.15） ，以及aPL和认知功能障碍（5个研究，OR = 1.97; 95％CI = 1.55-2.52）。我们还结合了认知功能障碍和痴呆症结局，因为它们都代表了认知障碍。 aPL和认知障碍之间有显着关联（6个研究; OR = 2.03; 95％CI = 1.62-2.55），SLE和认知障碍之间有显着关联（7个研究; OR = 1.83; 95％CI = 1.42-2.35）。在SLE和认知障碍之间的关联中发现中度异质性（I 2 = 45.7％），在SLE和痴呆之间的关联中发现低异质性（I 2 = 21.8％），而其他三个主要分析的异质性几乎为零。结论：SLE和aPL均与认知障碍有关。

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