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首页> 外文期刊>Journal of enzyme inhibition and medicinal chemistry. >A novel anti-platelet aggregation target of chinensinaphthol methyl ether and neojusticin B obtained from Rostellularia procumbens (L.) Nees
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A novel anti-platelet aggregation target of chinensinaphthol methyl ether and neojusticin B obtained from Rostellularia procumbens (L.) Nees

机译：一种新型的抗陈皮萘酚甲醚和新正义霉素B的抗血小板聚集靶标，来自于Rostellularia procumbens（L.）Nees

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This study explored the possible bioactive ingredients and target protein of Rostellularia procumbens (L.) Nees. The results of optical turbidimetry revealed that the ethyl acetate extraction obtained from R. procumbens (L.) Nees could inhibit platelet aggregation. Gene chip was used to investigate differentially expressed genes. According to the results of the gene chip, the targets of compounds isolated from the ethyl acetate extraction were predicted by network pharmacology. Computational studies revealed that chinensinaphthol methyl ether and neojusticin B may target the integrin αIIbβ3 protein. The results of Prometheus NT.48 and microscale thermophoresis suggested that the molecular interactions between the two compounds with purified integrin αIIbβ3 protein in the optimal test conditions were coherent with the docking results. To our best knowledge, this is the first report to state that chinensinaphthol methyl ether and neojusticin B target the integrin αIIbβ3 protein.
机译：这项研究探索了野蔷薇（Nestellularia procumbens（L.）Nees）的可能的生物活性成分和目标蛋白。光学比浊法的结果表明，从前枯草芽孢杆菌（L.）Nees获得的乙酸乙酯提取物可以抑制血小板聚集。基因芯片用于研究差异表达的基因。根据基因芯片的结果，通过网络药理学预测了从乙酸乙酯提取物中分离出的化合物的目标。计算研究表明，chinensinaphthol甲醚和新正义霉素B可能靶向整合素αIIbβ3蛋白。 Prometheus NT.48和微尺度热电泳的结果表明，在最佳测试条件下，两种化合物与纯化的整合素αIIbβ3蛋白之间的分子相互作用与对接结果一致。尽我们所知，这是第一个报告指出，chinensinaphthol甲醚和neojusticin B靶向整联蛋白αIIbβ3蛋白。

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