• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dementia & Neuropsychologia >Analysis of the posterior cingulate cortex with [ 18 F]FDG-PET and Naa/mI in mild cognitive impairment and Alzheimer's disease: Correlations and differences between the two methods
【24h】

Analysis of the posterior cingulate cortex with [ 18 F]FDG-PET and Naa/mI in mild cognitive impairment and Alzheimer's disease: Correlations and differences between the two methods

机译：[18 F] FDG-PET和Naa / mI在轻度认知障碍和阿尔茨海默氏病中分析后扣带回皮层：两种方法的相关性和差异

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

ABSTRACT Reduction of regional brain glucose metabolism (rBGM) measured by [18F]FDG-PET in the posterior cingulate cortex (PCC) has been associated with a higher conversion rate from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Magnetic Resonance Spectroscopy (MRS) is a potential biomarker that has disclosed Naa/mI reductions within the PCC in both MCI and AD. Studies investigating the relationships between the two modalities are scarce. OBJECTIVE To evaluate differences and possible correlations between the findings of rBGM and NAA/mI in the PCC of individuals with AD, MCI and of cognitively normal volunteers. METHODS Patients diagnosed with AD (N=32) or MCI (N=27) and cognitively normal older adults (CG, N=28), were submitted to [18F]FDG-PET and MRS to analyze the PCC. The two methods were compared and possible correlations between the modalities were investigated. RESULTS The AD group exhibited rBGM reduction in the PCC when compared to the CG but not in the MCI group. MRS revealed lower NAA/mI values in the AD group compared to the CG but not in the MCI group. A positive correlation between rBGM and NAA/mI in the PCC was found. NAA/mI reduction in the PCC differentiated AD patients from control subjects with an area under the ROC curve of 0.70, while [18F]FDG-PET yielded a value of 0.93. CONCLUSION rBGM and Naa/mI in the PCC were positively correlated in patients with MCI and AD. [18F]FDG-PET had greater accuracy than MRS for discriminating AD patients from controls.
机译：摘要通过[18F] FDG-PET测量的后扣带回皮质（PCC）中局部脑葡萄糖代谢（rBGM）的降低与轻度认知障碍（MCI）到阿尔茨海默氏病（AD）的更高转化率相关。磁共振波谱（MRS）是一种潜在的生物标记物，已经公开了MCI和AD中PCC内Naa / mI的降低。缺乏研究两种方式之间关系的研究。目的评估AD，MCI患者和认知正常志愿者的PCC中rBGM和NAA / mI的发现之间的差异和可能的相关性。方法将诊断为AD（N = 32）或MCI（N = 27）和认知正常的成年人（CG，N = 28）的患者接受[18F] FDG-PET和MRS进行PCC分析。比较了这两种方法，并研究了模态之间的可能相关性。结果与CG相比，AD组在PCC中表现出rBGM降低，而在MCI组中则没有。与CG相比，MRS显示AD组的NAA / mI值较低，而MCI组则没有。发现PCC中rBGM与NAA / mI正相关。 PCC使AD患者与对照组之间的NAA / mI降低，ROC曲线下的面积为0.70，而[18F] FDG-PET的值为0.93。结论MCI和AD患者的PCC中的rBGM和Naa / mI呈正相关。 [18F] FDG-PET在区分AD患者和对照组方面比MRS具有更高的准确性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号