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Obstructive sleep apnea and neurodegenerative diseases: A bidirectional relation

机译:阻塞性睡眠呼吸暂停和神经退行性疾病:双向关系

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Sleep disorders are common during the clinical course of the main neurodegenerative diseases. Among these disorders, obstructive sleep apnea has been extensively studied in the last decade and recent knowledge regarding its relationship with the neurodegenerative process points a bidirectional relationship. Neurodegenerative diseases can lead to functional changes in the respiratory system that facilitate the emergence of apnea. On the other hand, obstructive sleep apnea itself can lead to acceleration of neuronal death due to intermittent hypoxia. Considering that obstructive sleep apnea is a potentially treatable condition, its early identification and intervention could have a positive impact on the management of patients with neurodegenerative diseases.
机译:在主要的神经退行性疾病的临床过程中,睡眠障碍很常见。在这些疾病中,近十年来对阻塞性睡眠呼吸暂停进行了广泛的研究,有关其与神经退行性过程关系的最新知识指出了双向关系。神经退行性疾病可导致呼吸系统功能改变,从而促进呼吸暂停的出现。另一方面,阻塞性睡眠呼吸暂停本身会由于间歇性缺氧而导致神经元死亡加速。考虑到阻塞性睡眠呼吸暂停是一种可能可以治疗的疾病,其早期识别和干预措施可能会对神经退行性疾病患者的治疗产生积极影响。

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