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Association between Chronic Obstructive Pulmonary Disease and Dementia: Systematic Review and Meta-Analysis of Cohort Studies

机译：慢性阻塞性肺疾病与痴呆之间的关联：队列研究的系统评价和荟萃分析

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Background: Chronic obstructive pulmonary disease (COPD) is a common disease among the elderly, which has been linked to cognitive decline. However, the relationship between COPD and dementia remains unclear. Summary: We conducted a systematic literature review by searching databases such as Pubmed, Embase, EBSCO, and Cochrane Library (from inception to April 18, 2018) for studies on COPD that also investigated the prevalence of dementia. We found 3 cohort studies including a total of 39,392 COPD patients. Then we applied the Newcastle-Ottawa Scale to evaluate the risk of bias. Key Messages: COPD patients faced a higher risk of dementia (HR 1.46; 95% CI 1.22–1.75; p 0.001). Subgroup analysis on gender determined that the association between COPD and dementia was stronger in male patients (HR 1.49, 95% CI 1.20–1.86, p 0.001) than in female patients (HR 1.41, 95% CI 1.27–1.57, p 0.001). A subset study of patients aged 65 years revealed that the HR was greater for patients aged ≥75 years (HR 1.46, 95% CI 1.07–2.00, p = 0.02) than for those aged 65–74 years (HR 1.40, 95% CI 1.28–1.53, p 0.001). The cohort studies included were from similar population-based databases, suggesting possible regional limitations and publication bias.
机译：背景：慢性阻塞性肺疾病（COPD）是老年人中的常见疾病，与认知能力下降有关。然而，COPD与痴呆之间的关系仍不清楚。摘要：我们通过搜索Pubmed，Embase，EBSCO和Cochrane图书馆（从成立到2018年4月18日）等数据库进行了系统的文献综述，以研究关于COPD的研究，该研究还调查了痴呆的患病率。我们发现了3个队列研究，包括39,392名COPD患者。然后我们应用纽卡斯尔-渥太华量表来评估偏见的风险。关键信息：COPD患者面临更高的痴呆风险（HR 1.46; 95％CI 1.22-1.75; p <0.001）。性别亚组分析确定，男性患者（HR 1.49，95％CI 1.20-1.86，p <0.001）比女性患者（HR 1.41，95％CI 1.27-1.57，p <0.001）更强。 ）。对年龄> 65岁的患者进行的子集研究显示，≥75岁的患者（HR 1.46，95％CI 1.07–2.00，p = 0.02）的HR高于65–74岁的患者（HR 1.40，95％ CI 1.28–1.53，p <0.001）。纳入的队列研究来自类似的基于人群的数据库，表明可能存在区域限制和出版偏倚。

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